Evidence map›Paper›PMID 40330998›Full record

ArticleThe archives of bone and joint surgery2025

The Role of Periarticular Injections for Postoperative Pain after Total Knee Arthroplasty.

E Carlos Rodriguez-Merchan

Abstract read
In one paragraph

Article in The archives of bone and joint surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

E Carlos Rodriguez-MerchanDepartment of Orthopedic Surgery, La Paz University Hospital, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periarticular multimodal drug injection (PMDI) is better than FNB (femoral nerve block) in pain relief after total knee arthroplasty (TKA). PMDI of bupivacaine [20 mL 0.5% bupivacaine hydrochloride - HCl (100 mg) following implantation plus incisional injection of 10 mL 0.5% bupivacaine HCl (50 mg) before wound closure] is more efficacious than PMDI after implantation. PMDI leads to less postoperative pain than IAI (intraarticular injection) and IAI + PMDI. PMDI of magnesium sulfate and sodium bicarbonate added to a conventional PMDI (ropivacaine, epinephrine, and dexamethasone) prolongs analgesia. No differences exist between gonyautoxin (GTX)2/3 (40 µg GTX 2/3 diluted in 30 mL of sodium chloride 0.9%) and a combination of 300 mg of levobupivacaine, 1 mg of epinephrine, and 60 mg ketorolac diluted in 150 mL of sodium chloride 0.9%.

Indexed as

Periarticular multimodal drug injectionPostoperative painTotal knee arthroplasty

Identifiers

PMID40330998
PMCPMC12050083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.