ArticleMalaysian family physician : the official journal of the Academy of Family Physicians of Malaysia2025
Avanafil use in patients with erectile dysfunction and co-morbidities: Clinical insights from multiple aetiologies - A case series.
Article in Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Erectile dysfunction (ED) is a prevalent medical problem affecting men globally, particularly those with co-morbidities such as cardiovascular disease, hypertension, dyslipidaemia and diabetes. This case series aimed to evaluate the effects of avanafil as a treatment option for patients with ED and other co-morbidities. Eight male patients from a family medicine clinic received either 100 mg or 200 mg avanafil based on their clinical indication. Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5) and Erection Hardness Score. The outcomes included changes in the IIEF-5 score upon avanafil treatment. Our findings demonstrated a significant increase in the 200 mg avanafil treatment group, with the IIEF-5 score increasing from 14.83±9.4 to 24.17±2.6 (P<0.05). However, no significant difference was observed in the 100 mg avanafil treatment group (P=0.7903) and the overall avanafil treatment group (100 mg + 200 mg avanafil; P=0.0501). No adverse events were reported among the patients. Avanafil is considered a potentially safe and effective treatment option for ED, particularly in individuals with co-morbidities.
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