Evidence map›Paper›PMID 40330932›Full record

ArticleAME case reports2025

PIK3CA inhibitor treatment for metastatic scrotal extramammary Paget's disease: a case report and literature review.

Yuanqiong Huang, Siying Dong, Jianqing Ren, Jinyan Li, Chenwang Wu, Hongbo Chen, Yujie Liu, Jia Yuan, Jun Huang, Lin Xiao

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in AME case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuanqiong HuangDepartment of Oncology, The First People's Hospital of Liangshan Yi Autonomous Prefecture, Xichang, China.ORCID https://orcid.org/0000-0002-6820-5710
Siying DongGuangdong Medical University, Zhanjiang, China.
Jianqing RenGuangdong Medical University, Zhanjiang, China.
Jinyan LiDepartment of Radiotherapy Center, Jiangmen Central Hospital, Jiangmen, China.
Chenwang WuDepartment of Radiotherapy Center, Jiangmen Central Hospital, Jiangmen, China.
Hongbo ChenDepartment of Radiotherapy Center, Jiangmen Central Hospital, Jiangmen, China.
Yujie LiuDepartment of Oncology Unit II, Jiangmen Central Hospital, Jiangmen, China.
Jia YuanDepartment of Oncology Unit II, Jiangmen Central Hospital, Jiangmen, China.
Jun HuangDepartment of Urology, Jiangmen Central Hospital, Jiangmen, China.
Lin XiaoDepartment of Radiotherapy Center, Jiangmen Central Hospital, Jiangmen, China.ORCID https://orcid.org/0009-0000-3892-7504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma that occurs in the genitals, axilla, and anus, where apocrine sweat glands are abundant. This disease is mainly characterized by localized lesions and rare distant metastasis. Scrotal Paget's disease is a rare type of EMPD, and there is no standard treatment for metastatic EMPD. Case Description: Here, we reported the genetic results of a patient with a Conclusions:

Indexed as

case reportExtramammary Paget’s disease (EMPD)literature reviewPIK3CAtreatment

Identifiers

PMID40330932
PMCPMC12053722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.