ArticleAME case reports2025
An extremely rare case of Rosai-Dorfman-Destombes disease in the spleen with secondary thrombocytopenia: a case report.
Article in AME case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Rosai-Dorfman-Destombes disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, multisystemic histiocytic disorder. It can affect multiple organs, including bones, the brain, nasal cavities, and breasts. But, RDD in the spleen with secondary thrombocytopenia is extremely rare. This report aimed to show some new symptoms to help in the early diagnosis of this disease. Case Description: A 68-year-old female patient presented with abdominal discomfort for over 2 months. Positron emission tomography-computed tomography (PET-CT) examination revealed multiple splenic lesions with no significant abnormalities elsewhere. The patient had a history of rheumatoid arthritis and diabetes. Physical examination showed no significant abnormalities. Blood tests upon admission revealed a platelet count of 39×10 Conclusions: This case indicates that in patients with multiple splenic space-occupying lesions and thrombocytopenia, particularly with a history of rheumatoid arthritis, the potential for this illness should be contemplated, even in the absence of conventional RDD lymph node symptoms.
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