Evidence map›Paper›PMID 40330894›Full record

ArticleiScience2025

A single-cell and tissue-scale analysis suite resolves Mixl1's role in heart development.

Magdalena E Strauss, Mai-Linh Nu Ton, Samantha Mason, Jaana Bagri, Luke T G Harland, Ivan Imaz-Rosshandler, Nicola K Wilson, Jennifer Nichols, Richard C V Tyser, Berthold Göttgens and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Magdalena E StraussEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK.
Mai-Linh Nu TonDepartment of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Samantha MasonDepartment of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Jaana BagriDepartment of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Luke T G HarlandDepartment of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Ivan Imaz-RosshandlerDepartment of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Nicola K WilsonDepartment of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Jennifer NicholsMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
Richard C V TyserCambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.
Berthold GöttgensDepartment of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
John C MarioniEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK.
Carolina GuibentifInstitute Biomedicine, Department of Microbiology and Immunology, Sahlgrenska Center for Cancer Research, University of Gothenburg, 413 90 Gothenburg, Sweden.

Funding

Wellcome Trust 220379
6 · The paper itself

Abstract

Perturbation studies using gene knockouts have become a key tool for understanding the roles of regulatory genes in development. However, large-scale studies dissecting the molecular role of development master regulators in every cell type throughout the embryo are technically challenging and scarce. Here, we systematically characterize the knockout effects of the key developmental regulators

Indexed as

Biocomputational methodGenomic analysisGenomics

Identifiers

PMID40330894
PMCPMC12051648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.