A functional seizure case in Wilson's disease.

Lucas D'Andrea, Raphael Mosqueira, Alcenor C Miranda Filho, Renato L Marchetti

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In one paragraph

Article in Epilepsy & behavior reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Lucas D'AndreaDepartment of Neuropsychiatry, Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.

Raphael MosqueiraDepartment of Neuropsychiatry, Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.

Alcenor C Miranda FilhoDepartment of Neuropsychiatry, Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.

Renato L MarchettiDepartment of Neuropsychiatry, Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wilson's disease (WD) is a rare disorder characterized by abnormal copper metabolism, leading to its accumulation in various tissues, particularly the brain and the liver. Psychiatric and neurological symptoms are common manifestations of WD. We present a case of a 22-year-old woman diagnosed with WD who exhibited neurological symptoms and experienced functional seizures (FS) that were misdiagnosed as epilepsy secondary to WD for almost two years. The patient's history of childhood trauma and interpersonal difficulties underscored the complex interplay between organic and psychogenic factors contributing to FS development. This case highlights the diagnostic challenges associated with the neuropsychiatric manifestations of Wilson's disease, as well as the complexities in differentiating functional seizures from epilepsy. It emphasizes the importance of comprehensive assessment and multidisciplinary care in optimizing patient outcomes.

Indexed as

CeruloplasminCopperFunctional neurological disorderFunctional SeizurePsychiatryPsychogenicPsychogenic non-epileptic seizureWilson’s disease

Identifiers

PMID40330876

DOI10.1016/j.ebr.2025.100768

PMCPMC12052689

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.