Evidence map›Paper›PMID 40330857›Full record

ArticlebioRxiv : the preprint server for biology2025

DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication.

Anthony Fernandez, Tingting Zhou, Steven Esworthy, Changxian Shen, Helen Liu, Jessica D Hess, Hang Yuan, Nian Liu, Guojun Shi, Mian Zhou and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Anthony FernandezDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Tingting ZhouDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Steven EsworthyDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Changxian ShenDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Helen LiuDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Jessica D HessDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Hang YuanDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Nian LiuDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Guojun ShiDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Mian ZhouDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Settapong KosiyatrakulDepartment of Cell Biology Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Vikas GaurCenter for Genetic Diseases, Chicago Medical School Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Joshua SommersHelicases and Genomic Integrity Section, Translational Gerontology Branch, National Institute on Aging, Bethesda, MD 20892, USA.
Winfried EdelmanMichael F. Price Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Guo-Min LiInstitute for Cancer Research, Chinese Institutes for Medical Research, Beijing, 10069, China.
Robert BroshHelicases and Genomic Integrity Section, Translational Gerontology Branch, National Institute on Aging, Bethesda, MD 20892, USA.
Weihang ChaiCenter for Genetic Diseases, Chicago Medical School Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Marietta Y W T LeeDepartment of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595.
Dong ZhangDepartment of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568.ORCID 0000-0002-4515-2070
Carl SchildkrautDepartment of Cell Biology Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Li ZhengDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.
Binghui ShenDepartments of Cancer Genetics and Epigenetics Beckman Research Institute, City of Hope, Duarte, CA 91007, USA.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Role of Nucleases in RNA Primer Removal and MutagenesisR01CA085344 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI SHEN, BINGHUI · 1999 to 2024
$7.7M
Functional Analysis of Structure Specific Nucleases in Genome Stability and CancersR50CA211397 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ZHENG, LI · 2016 to 2025
$3.3M
DNA Damage Response and Oncogenic SignalingT32CA186895 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BINGHUI SHEN, Jeremy Michael Stark · 2016 to 2026
$2.1M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA085344NCI NIH HHS R50 CA211397NCI NIH HHS T32 CA186895
6 · The paper itself

Abstract

G-quadruplexes (G4s) are widely existing stable DNA secondary structures in mammalian cells. A long-standing hypothesis is that timely resolution of G4s is needed for efficient and faithful DNA replication.

Identifiers

PMID40330857
PMCPMC12051496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.