ReviewSkin appendage disorders2025
Scarring Alopecia and Risk of Skin Cancer: A Literature Review.
Review in Skin appendage disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Skin cancer risk in alopecia areata: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Topical diclofenac gel for actinic damage in patients with alopecia.JAAD case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Primary scarring alopecia is characterized by irreversible hair follicle destruction and chronic inflammation, which may create a microenvironment conducive to skin cancer development. Non-melanoma skin cancers (NMSCs), such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), are influenced by factors like UV exposure and prolonged inflammation. The link between primary scarring alopecia and increased scalp skin cancer risk remains unclear. Summary: This review analyzed thirteen studies reporting NMSC in primary scarring alopecia subtypes, including lichen planopilaris, discoid lupus erythematosus, folliculitis decalvans, and erosive pustular dermatosis of the scalp. Chronic inflammation, UV exposure, and immunosuppressive therapies were identified as potential contributors to malignancy. Key Messages: Primary scarring alopecia may increase susceptibility to SCC and BCC, particularly in areas of prolonged inflammation or immunosuppression. Clinicians should emphasize sun protection, routine follow-up, and patient education to minimize risk and improve outcomes. Further research is needed to clarify these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.