Evidence map›Paper›PMID 40330849›Full record

ArticleJID innovations : skin science from molecules to population health2025

A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16

Georgios Kravvas, Boyu Xie, Clarisse Ganier, Henk van den Munckhof, Ellen van den Munckhof, Maurits de Koning, Sandra Jerkovic Gulin, Alex Freeman, Aiman Haider, Hussain Alnajjar and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Georgios KravvasDepartment of Dermatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Boyu XieCentre of Gene Therapy and Regenerative Medicine, King's College London, London, United Kingdom.
Clarisse GanierCentre of Gene Therapy and Regenerative Medicine, King's College London, London, United Kingdom.
Henk van den MunckhofCerba Research, Rijswijk, The Netherlands.
Ellen van den MunckhofCerba Research, Rijswijk, The Netherlands.
Maurits de KoningCerba Research, Rijswijk, The Netherlands.
Sandra Jerkovic GulinDepartment of Dermatology and Venereology, Ryhov County Hospital, Jönköping, Sweden.
Alex FreemanDepartment of Histopathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Aiman HaiderDepartment of Histopathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Hussain AlnajjarDepartment of Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Asif MuneerDepartment of Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Magnus LynchCentre of Gene Therapy and Regenerative Medicine, King's College London, London, United Kingdom.
Michael MillarQueen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Aamir AhmedCentre of Gene Therapy and Regenerative Medicine, King's College London, London, United Kingdom.
Christopher Barry BunkerDepartment of Dermatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Emerging evidence suggests a relationship between chronic, intermittent, occluded exposure of a susceptible epithelium to urine and male genital lichen sclerosus (MGLSc), although human papillomavirus (HPV) may also play a role. Aims and methods: This study investigated the association between MGLSc and HPV across the prepuce. Preputial samples from uncircumcised patients with MGLSc undergoing circumcision were tested for MGLSc distribution, HPV genotyping, RNAscope, and p16 Results: Preputial samples from 9 patients with MGLSc were analyzed, with 9 distinct areas per prepuce, yielding 81 samples. These included MGLSc, non-MGLSc, and indeterminate regions. Various mucosal and beta HPV types were detected, most commonly HPV24, HPV23, HPV36, and HPV9. HPV DNA was found in all patients, and high-risk HPV types were found in 6. No significant differences were observed in total HPV ( Discussion: HPV DNA was detected in a mosaic pattern across the prepuce, with no significant differences between MGLSc and non-MGLSc skin. The absence of transcriptional activity suggests that HPV in MGLSc is incidental and may not contribute toward pathogenesis.

Indexed as

Gene transcriptionInflammatory skin diseasesPapillomavirusRNA biologyTranscription

Identifiers

PMID40330849
PMCPMC12051593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.