Evidence map›Paper›PMID 40330823›Full record

ArticleFrontiers in oncology2025

Oligoadenylate synthetase-like aggravated Newcastle disease virus-induced necroptosis in glioma cells.

Zecheng Yu, Yuxin Chen, Sisi Chen, Wenjing Ye, Ruirui Li, Yutang Fu, Yangkun Chen, Wenhao Fu, Xianqiao Wei, Qin Yu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Programmed cell death in paramyxovirus infection].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zecheng YuSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yuxin ChenSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Sisi ChenCenter of Laboratory Animal, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Wenjing YeSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Ruirui LiSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yutang FuSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yangkun ChenSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Wenhao FuSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Xianqiao WeiSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Qin YuSchool of Information Engineering, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yili CaiSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Lingyun WangSchool of Medical Laboratory and Biological Engineering, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yuheng ZhangSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Huazhong YingCenter of Laboratory Animal, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Fangwei DaiCenter of Laboratory Animal, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Wei HanCenter of Laboratory Animal, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Newcastle disease virus (NDV) has emerged as a tumor-lysing agent in a variety of cancers. Previous studies have shown that NDV has cytolytic activity in gliomas; however, the underlying mechanisms have not been fully elucidated. Methods: Comparing the glioma cells LN229 controlled group with the infected group of NDV rLa Sota-GFP strain, we strive to observe the changes in the genome and protein levels as well as the activation of the signalling pathways before and after the infection at the cellular level and at the level of the genes in the transcriptome, to study the molecular mechanism of necroptosis of the NDV-infected lethal LN229. Results: We found that NDV infection which inhibited glioma cells LN229 proliferation and promoted apoptosis in a dose-dependent manner involved mitochondrial disruption by a molecular mechanism, whereas the Fe Conclusion: Our study demonstrates that NDV has cytolytic activity on glioma cells by inducing necroptosis. Additionally, targeting upregulation of OASL may provide a novel strategy to enhance necrotic apoptosis in glioma cells after NDV infection.

Indexed as

cytolytic activitygliomaNDVnecroptosisOASL

Identifiers

PMID40330823
PMCPMC12053153

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.