Evidence map›Paper›PMID 40330736›Full record

ArticleHemaSphere2025

TET3 regulates hematopoietic stem cell homeostasis during embryonic and adult hematopoiesis.

Harmony C Ketchum, Claudia Morganti, Chie Yanase, Blake Ebert, Keisuke Ito, Meelad M Dawlaty

Abstract read
In one paragraph

Article in HemaSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Harmony C KetchumRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Albert Einstein College of Medicine Bronx New York USA.
Claudia MorgantiRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Albert Einstein College of Medicine Bronx New York USA.
Chie YanaseRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Albert Einstein College of Medicine Bronx New York USA.
Blake EbertRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Albert Einstein College of Medicine Bronx New York USA.
Keisuke ItoRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Albert Einstein College of Medicine Bronx New York USA.
Meelad M DawlatyRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Albert Einstein College of Medicine Bronx New York USA.ORCID 0000-0003-3121-2500

Funding

The Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem CellsR01DK098263 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Keisuke Ito · 2013 to 2026
$5.2M
Dissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disordersR01HL148852 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Meelad Dawlaty, Keisuke Ito · 2019 to 2026
$4.4M
Role of Tet enzymes in embryonic hematopoiesisR01HL172730 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Meelad Dawlaty · 2024 to 2026
$1.7M
NHLBI NIH HHS R01 HL148852NHLBI NIH HHS R01 HL172730NIDDK NIH HHS R01 DK098263
6 · The paper itself

Abstract

The ten-eleven translocation family of enzymes (TET1/2/3) promotes DNA demethylation and is essential for hematopoiesis. While the roles of TET1 and TET2 are well-studied in hematopoiesis, the requirement of TET3 in embryonic and adult hematopoiesis is less investigated. In this study, by characterizing embryonic and adult hematopoiesis in

Identifiers

PMID40330736
PMCPMC12053453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.