Evidence map›Paper›PMID 40330647›Full record

ArticleFrontiers in psychiatry2025

Case Report: The intersection of psychiatry and medicine: diagnostic and ethical insights from case studies.

Francesco Monaco, Annarita Vignapiano, Martina D'Angelo, Fabiola Raffone, Valeria Di Stefano, Antonella Boccia, Anna Longobardi, Benedetta Di Gruttola, Michele Fornaro, Giulio Corrivetti and 3 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. An Overview of Severe Myalgic Encephalomyelitis.Journal of clinical medicine · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Francesco Monaco *Department of Mental Health, Azienda Sanitaria Locale (ASL) Salerno, Salerno, Italy.
Annarita Vignapiano *Department of Mental Health, Azienda Sanitaria Locale (ASL) Salerno, Salerno, Italy.
Martina D'AngeloPsychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Fabiola RaffoneDepartment of Mental Health, Azienda Sanitaria Locale (ASL) Napoli 1 Centro, Napoli, Italy.
Valeria Di StefanoPsychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Antonella BocciaDepartment of Mental Health, Azienda Sanitaria Locale (ASL) Salerno, Salerno, Italy.
Anna LongobardiDepartment of Mental Health, Azienda Sanitaria Locale (ASL) Salerno, Salerno, Italy.
Benedetta Di GruttolaDepartment of Mental Health, Azienda Sanitaria Locale (ASL) Salerno, Salerno, Italy.
Michele FornaroSection of Psychiatry, Department of Neuroscience, Reproductive Science, and Dentistry, Federico II University of Naples, Naples, Italy.
Giulio CorrivettiDepartment of Mental Health, Azienda Sanitaria Locale (ASL) Salerno, Salerno, Italy.
Iolanda MartinoDepartment of Medical Sciences, Institute of Neurology, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Luca SteardoDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy.
Luca SteardoPsychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intersection of psychiatry and medicine presents unique diagnostic and ethical challenges, particularly for conditions involving significant brain-body interactions, such as psychosomatic, somatopsychic, and complex systemic disorders. This article explores the historical and contemporary issues in diagnosing such conditions, emphasizing the fragmentation of medical and psychiatric knowledge, biases in clinical guidelines, and the mismanagement of complex illnesses. Diagnostic errors often arise from insufficient integration between general medicine and psychiatry, compounded by the reliance on population-based guidelines that neglect individual patient needs. Misclassification of conditions like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Lyme disease, and fibromyalgia as psychosomatic or psychogenic has led to stigmatization and delayed care. While these conditions are referenced as emblematic examples of misclassified and poorly understood disorders, the five clinical cases discussed in this article do not directly illustrate these diseases. Instead, they exemplify shared diagnostic and ethical dilemmas at the medicine-psychiatry interface, including uncertainty, fragmentation, and the risk of epistemic injustice. The article critically examines terms like medically unexplained symptoms and functional disorders, highlighting their limitations and potential for misuse. Case examples underscore the consequences of diagnostic inaccuracies and the urgent need for improved approaches. Ethical considerations are also explored, emphasizing respecting patient experiences, promoting individualized care, and acknowledging the inherent uncertainties in medical diagnosis. Advances in technologies such as brain imaging and molecular diagnostics offer hope for bridging the gap between psychiatry and medicine, enabling more accurate assessments and better patient outcomes. The article concludes by advocating comprehensive training at the medicine-psychiatry interface and a patient-centered approach that integrates clinical observation, research insights, and a nuanced understanding of mind-body dynamics.

Indexed as

complex systemic disordersdiagnostic challengesethical implicationsmedicine-psychiatry interfacepsychosomatic disorderssomatopsychic conditions

Identifiers

PMID40330647
PMCPMC12053010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.