Evidence map›Paper›PMID 40330597›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Low TET1 Expression Levels in COPD Are Associated with Airway and Blood Neutrophilia.

Hong Ji, Xue Zhang, Angela L Linderholm, Maya Juarez, Michael Schivo, Brooks Kuhn, Richart W Harper, Amir A Zeki, Angela Haczku

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong JiUC Davis Lung Center, University of California, Davis, CA.ORCID 0000-0002-9558-0620
Xue ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Angela L LinderholmUC Davis Lung Center, University of California, Davis, CA.
Maya JuarezUC Davis Lung Center, University of California, Davis, CA.
Michael SchivoUC Davis Lung Center, University of California, Davis, CA.
Brooks KuhnUC Davis Lung Center, University of California, Davis, CA.
Richart W HarperUC Davis Lung Center, University of California, Davis, CA.
Amir A ZekiUC Davis Lung Center, University of California, Davis, CA.
Angela HaczkuUC Davis Lung Center, University of California, Davis, CA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
IND enabling development of LGM2605 as adjuvant treatment for asthmaR42AI132012 · NIAID · LIGNAMED, LLC · PI HACZKU, ANGELA, SIELECKI, THAIS MOTRIA · 2019 to 2021
$3.0M
Role of TET1 in airway epithelium and childhood asthmaR01AI141569 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JI, HONG · 2019 to 2023
$3.0M
Reducing Airway Smooth Muscle Tone Using Inhaled StatinsR01HL148715 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZEKI, AMIR A. · 2020 to 2024
$2.3M
NHLBI NIH HHS R01 HL148715NIAID NIH HHS R01 AI141569NIAID NIH HHS R42 AI132012NIH HHS P51 OD011107
6 · The paper itself

Abstract

Epigenetic dysregulation, particularly DNA methylation variations, is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Ten-eleven translocation (TET) proteins (TET1, TET2, and TET3) regulate DNA methylation and gene transcription. Impaired TET1 expression was previously associated with airway inflammation and asthma. Here we investigated TET gene associations with COPD severity. We found that reduced TET1 expression in peripheral blood mononuclear cells was associated with higher sputum and blood neutrophil counts, decreased lung function and increased disease severity in patients. These findings support a potential protective role and warrant further mechanistic investigations into the actions of TET1 in COPD.

Identifiers

PMID40330597
PMCPMC12051492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.