Evidence map›Paper›PMID 40330540›Full record

ArticleThe journal of allergy and clinical immunology. Global2025

Assessing diagnostic tests for shrimp allergy in children: A multicenter trial.

Yuri Takaoka, Yuki Tsurinaga, Yukiko Hiraguchi, Masaaki Hamada, Atsuko Nakano, Tomoko Kawakami, Ikuo Okafuji, Nayu Iwakoshi, Masaaki Doi, Keita Otsuka and 10 more

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Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Yuri TakaokaDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Yuki TsurinagaDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Yukiko HiraguchiDepartment of Pediatrics, Osaka Saiseikai Nakatsu Hospital, Shibata, Kita, Osaka, Japan.
Masaaki HamadaDepartment of Pediatrics, Yao Municipal Hospital, Ryuge, Yao, Osaka, Japan.
Atsuko NakanoDepartment of Pediatrics, Kokuho Chuo Hospital, Daimonjimiyako, Tawaramoto, Shiki, Nara, Japan.
Tomoko KawakamiDepartment of Pediatrics, Sumitomo Hospital, Nakanoshima, Kita, Osaka, Japan.
Ikuo OkafujiDepartment of Pediatrics, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Minatoshima, Chuo, Kobe, Hyogo, Japan.
Nayu IwakoshiDepartment of Pediatrics, Higashiosaka City Medical Center, Nishiiwata, Higashiosaka, Osaka, Japan.
Masaaki DoiDepartment of Pediatrics, Higashiosaka City Medical Center, Nishiiwata, Higashiosaka, Osaka, Japan.
Keita OtsukaDepartment of Pediatrics, Nara City Hospital, Higashikidera, Nara, Japan.
Yukiko SugimotoDepartment of Pediatrics, Hoshigaoka Medical Center, Hoshigaoka, Hirakata, Osaka, Japan.
Norihito IbaMinnanokodomo Allergy Clinic, Tomoda, Wakayama, Japan.
Junko KumonDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Rumi UenoDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Tamana NakanoDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Tomohiro YamaguchiDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Yohei FuksawaDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Amane ShigekawaDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Yukinori YoshidaDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.
Makoto KamedaDepartment of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Clinical research on pediatric shrimp allergy is limited. Objective: We sought to evaluate the diagnostic accuracy and safety of testing methods for shrimp allergy. Methods: An oral food challenge (OFC) for shrimp was conducted on Japanese children with suspected shrimp allergy. Before the OFC, shrimp-, tropomyosin-, house dust mite-, and cockroach-specific IgE levels were measured, along with skin prick tests (SPTs). OFC results using epinephrine as a safety indicator determined persistent, mild, or tolerant shrimp allergy. Results: Sixty-six children (median age, 6 years) underwent the OFC. All patients demonstrated house dust mite-specific IgE level exceeding 0.35 IUA/mL. Sixteen were diagnosed with persistent shrimp allergy, defined by Anaphylaxis Scoring Aichi scores greater than or equal to 10 or scores of 5 with urticaria. A 15-year-old required epinephrine for anaphylaxis. Eight children with negative results (scores ≤ 9) reported mild symptoms after repeated home ingestion following the OFC. Median SPT wheal diameters in persistent, mild allergic, and tolerant groups were similarly elevated (8.5 vs 9.5 vs 8.0 mm; Conclusions: SPT showed limited symptom correlation, whereas shrimp-specific IgE demonstrated greater diagnostic value than tropomyosin-specific IgE. No IgE cutoff accurately predicts a successfully passed OFC.

Indexed as

allergic reaction symptomsIgEROC-curve analysisShrimp hypersensitivityskin prick test (SPT)tropomyosin

Identifiers

PMID40330540
PMCPMC12053699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.