Evidence map›Paper›PMID 40330461›Full record

ReviewFrontiers in immunology2025

Tissue-resident immune cells in cervical cancer: emerging roles and therapeutic implications.

Xidie Li, Juan Deng, Xiaoping Liu, Yan Zhou, Tingting Bi, Jingjing Chen, Jinjin Wang

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xidie LiDepartment of Obstetrics and Gynecology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Juan DengDepartment of Obstetrics and Gynecology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Xiaoping LiuDepartment of Obstetrics and Gynecology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Yan ZhouDepartment of Obstetrics and Gynecology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Tingting BiDepartment of Obstetrics and Gynecology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Jingjing ChenDepartment of Breast Surgery, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Jinjin WangDepartment of Obstetrics and Gynecology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The favorable prognosis of "hot" tumors is widely acknowledged in oncology. Recently, the concept of tertiary lymphoid structures (TLS) has renewed appreciation for local immune cells within tumor tissues. Tissue-resident immune cells, a newly identified subset of tumor-infiltrating lymphocytes, are emerging as potential key players in tumor infiltration and TLS formation, due to their ability to reside indefinitely within tissues and mount effective responses to local antigens. Cervical cancer (CC), the fourth most common cause of cancer-related mortality among women globally, has experienced comparatively limited progress in delineating its tumor immune microenvironment compared to other malignancies. Notably, the role of tissue-resident immune cells within the CC milieu remains inadequately characterized. This comprehensive review aims to synthesize current knowledge and critically evaluate the putative roles of these cells in CC pathogenesis, providing new insights on the intricate dynamics of the local tumor microenvironment.

Indexed as

Lymphocytes, Tumor-InfiltratingTumor MicroenvironmentUterine Cervical NeoplasmsAnimalsFemaleHumansTertiary Lymphoid Structurescervical cancerlocal tumor microenvironmenttissue-resident immune cellstissue-resident memory T cellsTrm cell differentiation

Identifiers

PMID40330461
PMCPMC12053169

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.