Evidence map›Paper›PMID 40330444›Full record

ReviewContemporary oncology (Poznan, Poland)2025

Nivolumab resistance in head and neck squamous cell carcinoma patients and future perspectives.

Karolina Buchajska, Anna Mydlak, Jakub Zwoliński, Kinga Wojtaszczyk, Bartosz Spławski

Abstract readReview
In one paragraph

Review in Contemporary oncology (Poznan, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karolina BuchajskaMedical University of Warsaw, Faculty of Medicine, English Division, Warszawa, Poland.
Anna MydlakHead and Neck Cancer Department, The Maria Skłodowska-Curie National Research Institute of Oncology, Warszawa, Poland.
Jakub ZwolińskiHead and Neck Cancer Department, The Maria Skłodowska-Curie National Research Institute of Oncology, Warszawa, Poland.
Kinga WojtaszczykHead and Neck Cancer Department, The Maria Skłodowska-Curie National Research Institute of Oncology, Warszawa, Poland.
Bartosz SpławskiHead and Neck Cancer Department, The Maria Skłodowska-Curie National Research Institute of Oncology, Warszawa, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancer (HNC) cases are increasing globally, with resistance to immunotherapies such as nivolumab posing a significant challenge. This systematic review examines the mechanisms of nivolumab resistance in HNC, with a focus on intrinsic tumor factors, the immunosuppressive tumor microenvironment (TME), and immune checkpoint dysregulation. Intrinsic mechanisms, such as mutations that impair antigen presentation and

Indexed as

emerging therapies in HNSCCfuture perspectives in immunotherapyhead and neck squamous cell carcinoma (HNSCC)immunotherapy in HNSCCmechanisms of drug resistancenivolumab resistanceovercoming immunotherapy resistancePD-1/PD-L1 pathway

Identifiers

PMID40330444
PMCPMC12051880

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.