Evidence map›Paper›PMID 40330419›Full record

ArticleCureus2025

Senescence Accelerates the Occurrence of Dual Amyloidosis: Alzheimer's Disease and Wild-Type Transthyretin Amyloidosis.

Yohei Misumi, Yukio Ando, Naoya Nakashima, Yusuke Sugimura, Ryo Shirahama, Ryo Noguchi, Hirofumi Matsuda, Keiko Ando, Naoko Tsunoda, Yasuhiro Izumiya and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yohei MisumiDepartment of Neurology, Kumamoto University, Kumamoto, JPN.
Yukio AndoDepartment of Neurology, Amyloidosis Supporting Center, Sugimura Hospital, Kumamoto, JPN.
Naoya NakashimaDivision of Cardiology, Sugimura Hospital, Kumamoto, JPN.
Yusuke SugimuraDivision of Neurology, Sugimura Hospital, Kumamoto, JPN.
Ryo ShirahamaDivision of Neurology, Sugimura Hospital, Kumamoto, JPN.
Ryo NoguchiDivision of Cardiology, Sugimura Hospital, Kumamoto, JPN.
Hirofumi MatsudaDivision of Cardiology, Sugimura Hospital, Kumamoto, JPN.
Keiko AndoDivision of Gastroenterology, Sugimura Hospital, Kumamoto, JPN.
Naoko TsunodaDepartment of Psychiatry, Mitsugumachi Clinic, Kumamoto, JPN.
Yasuhiro IzumiyaDepartment of Cardiovascular Medicine, Kumamoto University, Kumamoto, JPN.
Kenichi TsujitaDepartment of Cardiovascular Medicine, Kumamoto University, Kumamoto, JPN.
Mitsuharu UedaDepartment of Neurology, Kumamoto University, Kumamoto, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of dual amyloidosis with Alzheimer's disease and wild-type transthyretin (ATTRwt) amyloidosis. A 76-year-old man with Alzheimer's disease was referred for anti-amyloid-β therapy with lecanemab. He also had symptoms of congestive heart failure and a history of carpal tunnel syndrome, cubital tunnel syndrome, and lumbar spinal stenosis; raising Technetium-99m pyrophosphate myocardial scintigraphy showed abnormal uptake, and histopathologic examination revealed transthyretin (TTR) amyloid deposition in both myocardial and gastrointestinal biopsy specimens. Genetic testing for the

Indexed as

alzheimer’s diseasedementiadual amyloidosisheart failuretransthyretin amyloidosis

Identifiers

PMID40330419
PMCPMC12051751

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.