ReviewCureus2025
Predictive Factors for the Discontinuation of Renal Replacement Therapy in Critically Ill Adults: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a decline in kidney function. Acute kidney injury frequently occurs as a complication among patients who are hospitalized or critically ill. Consequently, we aimed to examine the factors that could predict the cessation of renal replacement therapy (RRT) in individuals with severe AKI. We conducted a systematic review and meta-analysis with a comprehensive literature search in PubMed, Excerpta Medica database (Embase), and the Cochrane Library to identify relevant studies exploring factors associated with a successful transition from continuous renal replacement therapy (CRRT). The search was conducted from each database from beginning until December 1, 2022. The research was carried out on adult critically ill patients taking RRT while being supported in an intensive care unit (ICU) environment.We identified a total of 11 studies through our search. The pooled analysis demonstrated several predictive factors for successful weaning from CRRT, including CRRT duration, urine output in the course of CRRT termination (with an increase of 100 mL/day), creatinine clearance, urinary creatinine (UCr), neutrophil gelatinase-associated lipocalin (NGAL), and ICU length of stay (p < 0.00001). We concluded that the correlation between predictive factors and the weaning process from CRRT is not yet well understood. Furthermore, evidence is scarce concerning the optimal threshold values for UO and serum creatinine levels to determine successful weaning from CRRT. These findings provide valuable guidance to clinicians in determining the appropriate timing for discontinuing RRT in ICU settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.