ArticleCureus2025
Methemoglobinemia in the Setting of Consumption of Poppers and Preservation Pellets.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methemoglobinemia can be either an acquired or congenital condition in which the state of the iron atom is altered pathologically, and it cannot adequately deliver oxygen molecules to peripheral tissues. This may be due to drug or environmental exposures, such as antibiotics and local anesthetics, or patients may have a congenital defect in specific hemoglobin proteins or enzymes. We present a patient who presented with peripheral cyanosis and respiratory distress without a clear initial cause. It was later identified that the patient had swallowed an entire bottle of 'poppers' with preservation pellets, which led to an acute state of methemoglobinemia. The patient was treated with methylene blue and placed on observation for airway management. With many recreational sources of potential causes of methemoglobinemia, including over-the-counter drugs and even vegetables, clinicians must take a thorough history to look for the root cause of the presenting symptomatology.
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