ReviewCureus2025
Efficacy of High-Dose Statins in Preventing Contrast-Induced Nephropathy Post-cardiac Catheterization.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Preventing Contrast-Induced Acute Kidney Injury in Egyptian Patients Undergoing Coronary Angiography: A Randomized Controlled Trial.Clinical drug investigation · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrast-induced nephropathy (CIN) is defined as an increase in serum creatinine (s-CR) of at least 0.5 mg/dL or a 25% or greater increase from baseline within 48-72 hours of contrast agent administration. High-dose statins have been proposed as a prophylactic measure against CIN. This updated systematic review and meta-analysis aimed to assess the efficacy of peri-procedurally administered high-dose statins in preventing CIN in patients who underwent cardiac catheterization. A comprehensive literature review of PubMed and Embase was conducted with a distinct focus on studies published in the last 15 years up to June 2024. The study included randomized controlled trials (RCTs) that assessed the impact of high-dose statin treatment during or around the time of cardiac catheterization on the rate of contrast-induced nephropathy (CIN). It excluded trials comparing low-dose statins or statins used in non-cardiac surgeries, as well as studies with missing data or unclear end points on CIN. The primary objective was to evaluate the efficacy of high-dose statins administered peri-angiography to prevent CIN. Random effects were used using the DerSimonian and Laird method. A subgroup analysis was performed to assess the effectiveness of high-dose statins in preventing CIN in patients on chronic statin therapy. Our pooled analysis of 2,312 participants revealed a significantly lower incidence of CIN (odds ratio (OR): 0.47, 95% confidence interval (CI): 0.30-0.72, P = 0.0007, I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.