Evidence map›Paper›PMID 40330302›Full record

ArticleFrontiers in psychology2025

Dynamic brain glymphatic changes and cognitive function in COVID-19 recovered patients: a DTI-ALPS prospective cohort study.

Chengcheng He, Jinmei Xie, Weiwei Fang, Baoqin Guo, Yangyang Shi, Anan Li, Hao Liu, Zhimin Zhu, Wenrui Bao, Xuan Niu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chengcheng HeDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Jinmei XieDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Weiwei FangDepartment of Medical Imaging, Xinyuan Hospital of Yulin, Yulin, China.
Baoqin GuoDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Yangyang ShiDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Anan LiDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Hao LiuDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Zhimin ZhuDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Wenrui BaoSchool of Future Technology, Xi'an Jiaotong University, Xi'an, China.
Xuan NiuSchool of Future Technology, Xi'an Jiaotong University, Xi'an, China.
Shaoyu WangMR Research Collaboration, Siemens Healthineers, Shanghai, China.
Juan FuDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.
Hua LiDepartment of Medical Imaging, The First Hospital Of Yulin, Yulin, China.
Wenjuan XieDepartment of Medical Imaging, Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate brain glymphatic function in COVID-19 recovered patients using the non-invasive Diffusion Tensor Imaging-Analysis Along the Perivascular Space (DTI-ALPS) technique. The DTI-ALPS technique was employed to investigate changes in brain glymphatic function in these patients and explore correlations with cognitive function and fatigue. Materials and methods: Follow-up assessments were conducted at 1, 3, and 12 months post-recovery. A total of 31 patients completed follow-ups at all three time points, with 30 healthy controls (HCs) for comparison. Results: Compared to HCs, COVID-19 recovered patients showed a significant decline in MoCA scores at 3 months post-recovery ( Conclusion: This study demonstrates dynamic changes in brain glymphatic function in COVID-19 recovered patients, with a peak in activity at 3 months post-recovery. These changes are associated with cognitive function and mental fatigue, suggesting potential targets for addressing neurological symptoms of long COVID. The non-invasive DTI-ALPS technique proves to be a valuable tool for assessing brain glymphatic function in this population.

Indexed as

brain glymphatic functioncognitive functionCOVID-19 recovered patientsDTI-ALPSfatigue

Identifiers

PMID40330302
PMCPMC12053492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.