Evidence map›Paper›PMID 40330246›Full record

ArticleFrontiers in neurology2025

Delayed ischemic stroke after PED placement for aneurysms: optimal duration of dual antiplatelet therapy and risk factors.

Chao Wang, Yangyang Zhou, Ying Zhang, Dachao Wei, Mirzat Turhon, Jian Liu, Yisen Zhang, Kun Wang, Hongqi Zhang, Tianxiao Li and 13 more

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In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

23 authors.

Chao Wang *Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yangyang Zhou *Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Ying ZhangDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Dachao WeiDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Mirzat TurhonDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jian LiuDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yisen ZhangDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Kun WangDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Hongqi ZhangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Tianxiao LiDepartment of Neurosurgery, Zhengzhou University People's Hospital, Zhengzhou, China.
Aisha MaimaitiliDepartment of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Guohua MaoDepartment of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
Donglei SongDepartment of Neurosurgery, Shanghai Donglei Brain Hospital, Shanghai, China.
Yunyan WangDepartment of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China.
Wenfeng FengDepartment of Neurosurgery, Nanfan Hospital, Guangzhou, China.
Yang WangDepartment of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
Huaizhang ShiDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jieqing WanDepartment of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jianmin LiuDepartment of Neurosurgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, China.
Sheng GuanDepartment of Neurointervention Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuanli ZhaoDepartment of Neurosurgery, Peking University International Hospital, Beijing, China.
Wenqiang Li *Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Xinjian Yang *Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Delayed ischemic stroke (DIS) is a rare complication that may occur in patients with cerebral aneurysms treated with the Pipeline Embolization device (PED). This study aims to evaluate the characteristics of DIS following PED placement and to investigate the optimal duration of dual antiplatelet therapy (DAPT) in relation to the incidence of DIS. Methods: We conducted a multicenter retrospective cohort study on consecutive cases of intracranial aneurysms treated with PED. Patients were divided into two groups based on the timing of DAPT switching to monotherapy: early (<6 months) and late (≥6 months). To adjust for potential biases between the groups, inverse probability of treatment weighting (IPTW) was applied. Kaplan-Meier survival analysis and multivariate Cox regression were used to calculate cumulative DIS rates, and risk factors for DIS. Results: A total of 1,146 consecutive patients with 1,296 aneurysms were included, of whom 12 (0.96%) who received PED developed DIS. The late-switch group had a lower DIS rate compared to the early-switch group [0.5% (4 of 752 patients) vs. 2.0% (8 of 394 patients), Conclusion: DIS is a rare complication among patients treated with PED for cerebral aneurysms. Extending the duration of DAPT to at least six months may safer for the patients with hypertension and immediate complete occlusion.

Indexed as

delayed ischemic strokedual antiplatelet therapyflow diverterintracranial aneurysmrare complication

Identifiers

PMID40330246
PMCPMC12053283

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