ArticleFood science & nutrition2025
Mulberry Extract Mitigates Glucose-Induced Oxidative Injury in Differentiated ARPE-19 Cells by Enhancing Antioxidant Defense: Implications for Diabetic Retinopathy.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Acteoside alleviates high glucose-induced ROS accumulation and ferroptosis in ARPE-19 cells by activating the NRF2 signaling pathway.Molecular biology reports · 2026Article
- Genome-Wide Identification of the MYB Family inGenes · 2026Article
- Environmental control of anthocyanin biosynthesis in mulberry: unraveling gene networks for food applications.Food chemistry. Molecular sciences · 2026Review
- Article
- Natural antioxidant products and nanomaterial-based delivery systems for the amelioration of diabetic retinopathy: mechanisms, applications, and translational perspectives.Frontiers in immunology · 2026Review
- Systematic validation of miR-503-5p abnormal expression in diabetic vascular complications: a meta-analysis and exploration of its targeted regulatory mechanism in retinopathy.Diabetology & metabolic syndrome · 2025Article
- Integrating clinical evidence with natural product therapies for elderly-onset type 2 diabetes.Frontiers in pharmacology · 2025Review
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Authors and funding
6 authors.
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Abstract
Diabetic retinopathy, or DR, is an eye disease that causes globally impaired vision and vision loss among working-age adults. The progression of DR is related to persistent metabolic disturbances resulting from hyperglycemia. In diabetic patients, retinal cells, including RPE, are continuously exposed to high glucose conditions, which trigger oxidative stress and injury and finally lead to DR. Mulberry is rich in phytochemicals that offer various health benefits and is a significant source of anthocyanins, known for their antioxidant properties. Our research aimed to assess the antioxidant effects and underlying mechanisms of mulberry extract (ME) on high glucose-induced oxidative injury in human retinal (differentiated ARPE-19) cells. Differentiated ARPE-19 was treated with ME at 5, 50, and 500 μg/mL for 24 h, followed by incubating with 25 mM glucose for 48 h. From the HPLC analysis, ME contained anthocyanin compounds, including C3G and C3R, at 8.13 and 9.86 mg/g of dry weight, respectively. ME could prevent differentiated ARPE-19 cells from oxidative injury by mitigating ROS generation, modulating protein expression in the apoptosis markers (Bax, cytochrome
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