ArticlePlastic and reconstructive surgery. Global open2025
Evaluation of Non-cross-linked Hyaluronic Acid on Oral Wound Healing After Diode Laser and Scalpel Incisions.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Plant Exosome Injections in Tongue Wounds: A Comparative Histological and Immunohistochemical Experimental Study.Plastic and reconstructive surgery. Global open · 2026Article
- Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation.Gels (Basel, Switzerland) · 2026Review
- Evaluation of the effect of laser irradiation with a wavelength of 445 nm on microcirculation and oxidative metabolism of gingiva according to laser doppler flowmetry.Lasers in medical science · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The aim was to assess the impact of non-cross-linked hyaluronic acid (HA) injections on the healing of intraoral wounds from 3 types of incisions. Methods: A total of 36 Wister albino rats were included in this research. The rats were randomly assigned to 1 of 6 groups: the first group underwent a scalpel incision in the buccal mucosa with HA injection. The second group received a laser incision using a 976-nm diode laser with HA injection, whereas the third group was subjected to a laser incision with a 450-nm diode laser with HA injection. The fourth group underwent scalpel incision only, the fifth group received a 976-nm laser incision only, and the sixth group received a 450-nm laser incision only. Biopsies were collected at baseline, as well as on the third and seventh days, to assess wound healing using hematoxylin and eosin and Masson trichrome staining. Results: Group 3 exhibited the most pronounced results on the third and seventh days after surgery, with collagen formation noted alongside well-organized granulation tissue that contributed to improved and expedited wound healing. Conclusions: In this low-volume experimental study, HA injections in wounds made with a 450-nm diode laser demonstrated encouraging outcomes, enhancing the healing process and resulting in quicker recovery.
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Registered trials
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