ArticlePlastic and reconstructive surgery. Global open2025
Meta-analysis of Objective Sensory Outcomes From 764 Breasts Shows Superior Sensation of Autologous Reconstruction With Neurotization.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07308275 (Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components: An Assessment of BREAST-Q Sensation Module, Cutaneous Pressure Threshold, Neuregulin 1 (NRG1) Expression, Nerve Fiber Cross-sectional Area, Intraepidermal Nerve Fiber Density (IENFD), and Breast Morphometry
Who cites it
3 citing papers in PubMed.
- Review
- How to approach the deep inferior epigastric perforator flap revision for optimal aesthetics.Gland surgery · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Breast and nipple-areolar complex (NAC) sensation after breast reconstruction impacts postoperative quality of life. Autologous breast reconstruction (ABR) and implant-based breast reconstruction (IBBR) are standard techniques. Neurotization has shown promise in improving sensory outcomes. Methods: A computerized search was conducted on March 20, 2024, using the following databases: PubMed (1994-2024), MEDLINE (1996-2024), Embase (1988-2024), Web of Science (1997-2024), Scopus (2004-2024), and CINAHL (1994-2024). The following terms were used: "Semmes-Weinstein" and "mastectomy" OR "Semmes-Weinstein" and "breast reconstruction." Studies that reported objective results from Semmes-Weinstein monofilament testing by breast and NAC quadrant at least 12 months postoperatively were included. Statistical analysis was performed using multivariate regression analysis incorporating variables that were found to be significant on univariate regression analysis. This was followed by pairwise comparisons using Tukey tests to directly compare ABR, IBBR, and ABR with neurotization. Results: Thirteen studies reporting on sensory outcomes of 764 reconstructed breasts met the aforementioned criteria. ABR with neurotization resulted in better sensation outcomes on the breast and NAC compared with either ABR or IBBR. When controlling for radiation, ABR without neurotization resulted in more sensate NAC region/central mound compared with IBBR. These findings suggest that ABR with neurotization following skin-sparing mastectomy results in better sensation at the new NAC compared with nipple-sparing mastectomy with ABR without neurotization. Conclusions: ABR with neurotization may result in superior breast sensation, which is associated with increased quality of life and satisfaction, compared with ABR without neurotization and IBBR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.