Evidence map›Paper›PMID 40330024›Full record

ArticleFrontiers in cellular and infection microbiology2025

Therapeutic approaches for septicemia induced by multidrug-resistant bacteria using desert-adapted plants.

Nesreen Safwat, Rana Elshimy, Soha O Hassanin, Arwa Ramadan El-Manakhly, Abdullah N Noaf, Abdallah Tageldein Mansour, Fatma Alshehri, Majid Alhomrani, Abdulhakeem S Alamri, Mahmoud Mohammed Bendary

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Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nesreen SafwatDepartment of Microbiology and Immunology, Faculty of pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Rana ElshimyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Alhram Canadian University, Giza, Egypt.
Soha O HassaninDepartment of Biochemistry, Faculty of pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Arwa Ramadan El-ManakhlyDepartment of Microbiology and Immunology, Faculty of pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Abdullah N NoafSurgical Department, Al Hadithah General Hospital, Al-Qurayyat, Saudi Arabia.
Abdallah Tageldein MansourFish and Animal Production Department, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia.
Fatma AlshehriDepartment of Biology, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Majid AlhomraniDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Science, Taif University, Taif, Saudi Arabia.
Abdulhakeem S AlamriDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Science, Taif University, Taif, Saudi Arabia.
Mahmoud Mohammed BendaryDepartment of Microbiology and Immunology, Faculty of Pharmacy, Port Said University, Port Said, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Septicemia, a life-threatening condition, can arise when bacterial infections are left untreated, allowing the pathogens to spread into the bloodstream. Moreover, infections caused by MDR bacteria are particularly challenging, as they can persist and lead to septicemia even when treated with conventional antibiotics. This study aimed to address this crisis by investigating combination therapies using desert-adapted medicinal plant extracts, including Methodology: In this study, 400 blood samples from septic patients were analyzed to identify Gram-negative bacterial isolates. Antimicrobial resistance patterns were assessed using standard susceptibility tests. Medicinal plant extracts were evaluated for antimicrobial activity using agar diffusion and broth microdilution assays, while COX-1 and COX-2 inhibition and antioxidant activity were measured using Results: We observed a high prevalence of Conclusion: We highlighted the potential of

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialPlant ExtractsPlants, MedicinalSepsisAgedAnimalsAntioxidantsDesert ClimateDisease Models, AnimalEscherichia coliFemaleGram-Negative BacteriaHumansKlebsiella pneumoniaeMaleAnti-Bacterial AgentsAntioxidantsPlant Extractsamikacingram-negativeJ. candicansmedicinal plantsseptic patients

Identifiers

PMID40330024
PMCPMC12052906

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.