Evidence map›Paper›PMID 40330005›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2025

The Relationship of Frailty with Surgical and Laser Treatment for Patients with Glaucoma.

Jonathan D Groothoff, James A Rhead, Isaiah J Miller, Nicholas D De la Osa, Jordan A Perry, Walter S Duy, Joni K Evans, Atalie C Thompson

Abstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathan D GroothoffDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
James A RheadDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Isaiah J MillerDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Nicholas D De la OsaDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jordan A PerryDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Walter S DuyDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Joni K EvansDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Atalie C ThompsonDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-2817-6417

Funding

CTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9M
NCATS NIH HHS UM1 TR004929
6 · The paper itself

Abstract

Introduction: The purpose of this study was to determine whether frailty, quantified by an electronic Frailty Index (eFI), was associated with the likelihood of receiving surgery or laser treatment in patients with glaucoma. Methods: Single-center retrospective review of patients presenting with glaucoma who had a calculable eFI. A repeated measures multivariable logistic regression model was used to determine the relationship between eFI score and the likelihood of having glaucoma surgery, and a multivariable survival model was also created to assess time to glaucoma surgery. Similar models were constructed for laser treatment (LT). Models were adjusted for age, race/ethnicity, sex, baseline intraocular pressure, and severity based on mean deviation. Results: A total of 1168 patients (2248 eyes) were included in this study. Glaucoma surgery was significantly more likely among those with severe [OR=2.89] or moderate glaucoma [OR=1.89] ( Conclusion: Increased age and frailty scores are associated with reduced likelihood of receiving glaucoma surgery or LT and longer time to glaucoma surgery, even after controlling for baseline IOP and glaucoma severity. Future studies should investigate whether frailty impacts surgical outcomes in glaucoma.

Indexed as

electronic frailty indexfrailtyglaucoma surgery

Identifiers

PMID40330005
PMCPMC12052001

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.