Evidence map›Paper›PMID 40329970›Full record

ArticleCureus2025

Prevalence of Bisphosphonate and Denosumab Use in Elderly Care Facilities: Implications for the Management of Medication-Related Osteonecrosis of the Jaw.

Motohiko Sano, Yosuke Iijima, Miki Yamada, Mihoko Kanbe, Tomoyuki Kanbe, Shunsuke Hino, Kiyoko Ariya, Norio Horie, Takahiro Kaneko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Motohiko SanoDivision of Applied Pharmaceutical Education and Research, Hoshi University, Tokyo, JPN.
Yosuke IijimaDepartment of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, JPN.
Miki YamadaDepartment of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, JPN.
Mihoko KanbeDepartment of Oral and Maxillofacial Surgery, Saitama Yorii Hospital, Saitama, JPN.
Tomoyuki KanbeDepartment of Oral and Maxillofacial Surgery, Saitama Yorii Hospital, Saitama, JPN.
Shunsuke HinoDepartment of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, JPN.
Kiyoko AriyaSpecial Elderly Care Home, Attaka No ie, Saitama, JPN.
Norio HorieDepartment of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, JPN.
Takahiro KanekoDepartment of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur group is investigating the contribution of pharmacists in reducing medication-related osteonecrosis of the jaw (MRONJ) associated with bisphosphonates (BPs) and denosumab (Dmab). Recently, our group encountered a case of MRONJ occurring in an elderly care setting. The aim of this study was therefore to investigate the actual use of BP and Dmab and the incidence of MRONJ in elderly care facilities. We also discussed measures for the prevention and early detection of MRONJ by dentists and pharmacists associated with these facilities. MATERIALS AND

methodsA cross-sectional survey across four elderly care facilities (including the one where the case occurred) was conducted to determine the prevalence of BP and Dmab use and related factors, as well as the incidence of MRONJ.

resultsAmong 327 residents, 9.8% (32) were receiving BP or Dmab therapy (84.4% oral, 15.6% injectable). The encountered MRONJ case was the only one identified, occurring in a resident using injectable BP.

conclusionIn these elderly facilities, 9.8% of residents used BPs or Dmab, with 15.6% receiving injectable formulations. One MRONJ case occurred with injectable BP use, suggesting the potential for sporadic MRONJ in elderly care. As BP/Dmab use is likely to increase, pharmacist intervention for prescription review and training for visiting dentists are considered effective strategies for MRONJ prevention and early detection.

Indexed as

bisphosphonate-related osteonecrosis of the jawelderly inpatientintravenous bisphosphonatepharmacist collaborationpharmacist role

Identifiers

PMID40329970
PMCPMC12051078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.