Evidence map›Paper›PMID 40329955›Full record

ArticleJournal of oral biology and craniofacial research

The profiling and analysis of gene expression in rat temporomandibular joint disc tissue and its derived cells.

Haruna Kashio, Rie Takai, Ayuko Takada, Yuya Nakao, Nattakarn Hosiriluck, Masahiro Iijima, Yoshihiro Abiko, Itaru Mizoguchi, Toshiya Arakawa

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Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Haruna KashioDivision of Biochemistry, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Japan.
Rie TakaiDivision of Biochemistry, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Japan.
Ayuko TakadaDivision of Biochemistry, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Japan.
Yuya NakaoDivision of Orthodontics and Dentofacial Orthopedics, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Japan.
Nattakarn HosiriluckDivision of Biochemistry, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Japan.
Masahiro IijimaDivision of Orthodontics and Dentofacial Orthopedics, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Japan.
Yoshihiro AbikoDivision of Oral Pathology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Japan.
Itaru MizoguchiDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, Japan.
Toshiya ArakawaDivision of Biochemistry, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The temporomandibular joint (TMJ) disc is composed of a fibrocartilaginous connective tissue. Its dysfunction, resulting from excessive jaw movement, can lead to TMJ disorders. In this study, we aimed to investigate the crucial molecular information regarding the extracellular matrix (ECM), which would be necessary for treating such disorders through TMJ disc regeneration. To achieve this, we compared the gene profiles of TMJ disc tissues, their derived cells, and the periodontal ligament (PDL) in our previous study. Methods: TMJ discs were isolated from male Wistar rats. Cells derived from the TMJ discs were cultured, and mRNA extracted from the disc tissues and derived cells was analyzed for gene profiling via microarray hybridization. Additionally, we compared the ECM expression between the TMJ disc and the PDL. Results: Collagen (types I, II, III, and VI) and proteoglycans (biglycan and fibromodulin) were highly expressed in the TMJ discs. Significant reduction in decorin, fibromodulin and COL2 were observed in the TMJ-derived cells than in the tissue. Type VI collagen was the third most highly expressed in both the TMJ disc and PDL tissues, following types I and III. Conclusions: Collagen types VI and II were prominently expressed, followed by collagen types I and III, in TMJ disc tissues, reflecting the unique functions of the disc. Type VI collagen was highly expressed in both TMJ disc and PDL tissues. Overall, type VI collagen might be a key molecule for TMJ disc regeneration, ensuring elasticity and cushioning, and could provide new insights for TMJ regeneration.

Indexed as

CollagenGene expressionProteoglycanTemporomandibular joint disc

Identifiers

PMID40329955
PMCPMC12052981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.