Evidence map›Paper›PMID 40329845›Full record

ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2025

Placental biomarker and fetoplacental Doppler abnormalities are strongly associated with placental pathology in pregnancies with small-for-gestational-age fetus: prospective study.

J Hong, K Crawford, E Cavanagh, V Clifton, F da Silva Costa, A V Perkins, S Kumar

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In one paragraph

Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Angiogenic factors and fetal Doppler for predicting adverse pregnancy outcome in early-onset small fetuses with and without pre-eclampsia.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Observational
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J HongMater Research Institute, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0001-8585-2357
K CrawfordMater Research Institute, University of Queensland, Brisbane, Queensland, Australia.
E CavanaghMater Research Institute, University of Queensland, Brisbane, Queensland, Australia.
V CliftonMater Research Institute, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-4892-6748
F da Silva CostaSchool of Medicine and Dentistry, Griffith University and Maternal Fetal Medicine Unit, Gold Coast University Hospital, Gold Coast, Queensland, Australia.ORCID 0000-0002-0765-7780
A V PerkinsSchool of Health, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.
S KumarMater Research Institute, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-0832-4811

Funding

Mater FoundationNational Health and Medical Research Council
6 · The paper itself

Abstract

objectivePlacental dysfunction can result in small-for-gestational age (SGA) or fetal growth restriction (FGR). The aim of this prospective cohort study was to assess the association of the cerebroplacental ratio (CPR) and other more conventional fetoplacental Doppler indices, circulating placental growth factor (PlGF) levels and soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio, with specific placental abnormalities in a large cohort of pregnancies with an SGA/FGR fetus.

methodsThis was a prospective cohort study of singleton pregnancies with a SGA/FGR fetus conducted at the Centre for Maternal and Fetal Medicine at the Mater Mother's Hospital, Queensland, Australia. Multivariable logistic regression with adjustment for pre-eclampsia was used to evaluate the effect of CPR < 5

resultsAmong the 367 women included in this study, MVM was present in 159 (43.3%) placentae, FVM in 20 (5.4%), VUE in 49 (13.4%), DVM in 19 (5.2%) and CHI in six (1.6%). Compared to SGA controls with normal fetoplacental Doppler and placental biomarkers, CPR < 5

conclusionIn pregnancies with SGA/FGR fetus, mean UtA-PI > 95

Indexed as

Fetal Growth RetardationInfant, Small for Gestational AgePlacentaPlacenta DiseasesPlacenta Growth FactorAdultBiomarkersFemaleHumansInfant, NewbornPregnancyProspective StudiesUltrasonography, DopplerUltrasonography, PrenatalUmbilical ArteriesUterine ArteryBiomarkersFLT1 protein, humanPGF protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1cerebroplacental ratiofetal growth restrictionmaternal vascular malperfusionplacental dysfunctionplacental growth factorplacental pathologypregnancysmall‐for‐gestational agesoluble fms‐like tyrosine kinase‐1umbilical artery Doppler

Identifiers

PMID40329845
PMCPMC12127712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.