Evidence map›Paper›PMID 40329819›Full record

ReviewNanomedicine (London, England)2025

From conventional therapy to novel nano-based approaches. A focus on prostate cancer.

Lorenzo Chiaverini, Giarita Ferraro, Riccardo Di Leo, Elisabetta Barresi, Diego La Mendola, Francesco Bartoli, Luca Famlonga, Cristina Satriano, Pinuccia Faviana, Alessandro Zucchi and 4 more

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lorenzo ChiaveriniDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Giarita FerraroDepartment of Chemical Sciences, University of Naples 'Federico II', Napoli, Italy.
Riccardo Di LeoDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Elisabetta BarresiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Diego La MendolaDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Francesco BartoliDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Luca FamlongaDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Cristina SatrianoNanoHybrid BioInterfaces Laboratory (NHBIL), Department of Chemical Sciences, University of Catania, Catania, Italy.
Pinuccia FavianaDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Alessandro ZucchiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Matteo PaciniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Jürgen GailerDepartment of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada.
Chiara GiacomelliDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Tiziano MarzoDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-2567-3637

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The currently available clinical anticancer approaches pertaining to the treatment of prostate cancer are summarized here. After providing an overview of the main features of this highly impactful global disease, the currently available clinical treatments are briefly reviewed. Then, alternative and innovative nano-based therapeutic options that have been proposed or are currently being explored to significantly improve prostate cancer management (i.e. anti-prostate cancer polymeric nanoparticles loaded with drugs to promote their release and biological activity, including non-targeted and functionalized PLGA-PEG NPs and AuNPs), are introduced. Furthermore, the problem of gathering insights into the mechanistic aspects related to the fate of the nanoformulation in complex matrices, such as blood plasma, is addressed.

Indexed as

Antineoplastic AgentsNanoparticlesProstatic NeoplasmsAnimalsDrug CarriersDrug Delivery SystemsGoldHumansMaleNanomedicinePolyethylene GlycolsAntineoplastic AgentsDrug CarriersGoldPolyethylene GlycolschemotherapyICP-SECmetallomicsnanodeliverynanoparticlesPLGA-PEGProstate cancer

Identifiers

PMID40329819
PMCPMC12140480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.