Evidence map›Paper›PMID 40329815›Full record

ArticleJournal of neurotrauma2025

Correlating Magnetoencephalography, Diffusion Kurtosis Imaging, Biomechanics, and Neuropsychology in American Youth Football.

Natalie M Bell, Fang F Yu, Yin Xi, Amy L Proskovec, James M Holcomb, Sahil Chilukuri, Jillian E Urban, Christopher Vaughan, Jesse C DeSimone, Ben Wagner and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Natalie M BellAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-8890-6840
Fang F YuAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yin XiDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Amy L ProskovecAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
James M HolcombDepartment of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-5551-3936
Sahil ChilukuriAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jillian E UrbanDepartment of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Christopher VaughanDivision of Pediatric Neuropsychology, Children's National Hospital, Rockville, Maryland, USA.
Jesse C DeSimoneAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ben WagnerAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mark A EspelandDivision of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Alexander K PowersDepartment of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Christopher T WhitlowDepartment of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Joel D StitzelDepartment of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0001-9762-3033
Joseph A MaldjianAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Elizabeth M DavenportAdvanced Neuroscience Imaging Research Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-8765-6584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the association between repetitive head impacts (RHIs) and multimodal neuroimaging, biomechanical, and neuropsychological data in 72 youth football players and 17 controls, aged 8-12 years. Helmet sensors measured RHI exposure while imaging and psychological data were collected before and after the season. Risk-weighted exposure metrics were calculated to quantify cumulative RHI exposure. Changes in magnetoencephalography (MEG) and diffusion kurtosis imaging were analyzed by calculating voxel-wise difference, and z-score maps were thresholded with respect to controls. Using linear regression, statistically significant positive associations were observed between abnormally increased MEG-measured theta (5-7 Hz) power and RHI measures. No associations were found between RHI and other neuroimaging metrics. Football players and controls exhibited significant yet divergent associations between alpha (8-12 Hz) power as well as mean kurtosis and neuropsychological changes. These findings indicate a potential association between youth football players' exposure to RHI and neurophysiological alterations.

Indexed as

Brain ConcussionDiffusion Tensor ImagingFootballMagnetoencephalographyBiomechanical PhenomenaChildHumansMaleNeuropsychological TestsDiffusion MRIEEGfMRINIH FlankerSubconcussion

Identifiers

PMID40329815
PMCPMC12411097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.