Trial reportPediatric hematology and oncology2025
Reducing empiric antibiotic administration in pediatric oncology patients with non-neutropenic fever: a single-center quality improvement initiative.
Trial report in Pediatric hematology and oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
The management of non-neutropenic fever in pediatric oncology varies widely, with many providers choosing to administer empiric antibiotics. We conducted a quality improvement intervention seeking to decrease empiric antibiotic administration in pediatric oncology patients with a central venous catheter presenting in the outpatient setting with non-neutropenic fever assessed to be low-risk for bacteremia. Over a 1-year period, empiric antibiotics were administered at the index visit in 9.6% of episodes, compared with 97% prior to the intervention. In patients not receiving empiric antibiotics, the bacteremia rate was 2.3% and composite event rate 5.1%, similar to pre-intervention baseline. These data suggest that empiric antibiotics can be withheld in low-risk patients with non-neutropenic fever.
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