Evidence map›Paper›PMID 40329806›Full record

ArticleActa biochimica et biophysica Sinica2025

Causal effects of immune cells on the efficacy and adverse drug reactions of platinum drugs.

Wanting Li, Bing Yu, Qi Xiao, Zhao Zhang, Hanxue Huang, Jiajia Cui, Guangying Qi, Jifang Zheng, Jiye Yin, Zhaoqian Liu and 2 more

Abstract read
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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wanting LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Bing YuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Qi XiaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhao ZhangXiangya Medical School, Central South University, Changsha 410013, China.
Hanxue HuangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Jiajia CuiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Guangying QiGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541199, China.
Jifang ZhengGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541199, China.
Jiye YinDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhaoqian LiuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xi LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Howard L McLeodDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platinum drugs are widely used in lung cancer chemotherapy, but the immune characteristics of different individuals have different effects on the sensitivity and side effects of platinum drugs. In this study, we use 731 kinds of immune cell traits of 3757 healthy individuals and 429 patients with non-small cell lung cancer (NSCLC) in Xiangya Hospital of Central South University to conduct a Mendel randomized analysis in order to find out the causal relationship between some immune cell traits and the efficacy and adverse reactions of platinum drugs. We find that CD19 on CD24

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungLung NeoplasmsAdultAgedB-LymphocytesFemaleHumansMaleMiddle AgedAntineoplastic Agentsadverse drug reactionsGenome-Wide Association Studies (GWAS)immune cellsMendel randomizationplatinum drugs

Identifiers

PMID40329806
PMCPMC12536459

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.