Evidence map›Paper›PMID 40329661›Full record

Observational studyHead & neck2025

Multidimensional Prognostic Index as a Predictor of Mortality in Head and Neck Cancer Patients: A Cohort Study.

Ajay T Bakas, Aniel Sewnaik, Femke Flikweert, Robert Jan Baatenburg de Jong, Francesco Mattace-Raso, Harmke Polinder-Bos

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ajay T BakasDepartment of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC University Cancer Institute, Rotterdam, the Netherlands.ORCID 0000-0002-5241-4155
Aniel SewnaikDepartment of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC University Cancer Institute, Rotterdam, the Netherlands.
Femke FlikweertDivision of Geriatric Medicine, Department of Internal Medicine, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.
Robert Jan Baatenburg de JongDepartment of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC University Cancer Institute, Rotterdam, the Netherlands.ORCID 0000-0001-7236-264X
Francesco Mattace-RasoDivision of Geriatric Medicine, Department of Internal Medicine, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.ORCID 0000-0002-1688-6497
Harmke Polinder-BosDivision of Geriatric Medicine, Department of Internal Medicine, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.ORCID 0000-0002-7458-725X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead and neck cancer (HNC) significantly impacts older adults, with mortality influenced by multiple factors. The Multidimensional Prognostic Index (MPI), derived from comprehensive geriatric assessment (CGA), may improve risk stratification and clinical decision making.

methodsAn observational cohort study was conducted at Erasmus Medical Center, Rotterdam, from December 2019 to June 2021. We included 423 HNC patients aged 70 years or older or younger patients with a G8 score of 14 or less. MPI stages were determined through CGA, categorized into stages 1, 2, and 3.

resultsDuring a median follow-up of 595 days, 115 patients (29%) died. MPI stage 2 and stage 3 were associated with a higher mortality risk compared to MPI stage 1 (HR 2.18; 95% CI 1.46-3.26). In the surgical subgroup, similar mortality risks were observed, but MPI stages did not correlate with postoperative complications.

conclusionsMPI stages derived from CGA effectively predict mortality risk in older HNC patients, though they do not predict postoperative complications.

Indexed as

Geriatric AssessmentHead and Neck NeoplasmsAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedNeoplasm StagingNetherlandsPrognosisRisk Assessmentcomprehensive geriatric assessmentfrailtyhead and neck cancermortalitymultidimensional prognostic index

Identifiers

PMID40329661
PMCPMC12434554

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.