Evidence map›Paper›PMID 40329658›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two-cohort study.

Min Wei, Ying Zhang, Min Wang, Jiayi Zhong, Wenhui Chai, Wenjing Hu, Fengli Tao, Luyao Wang, Qi Zhang, Xianfeng Yu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Spotlight on Alzheimer's disease and related dementias research in East Asia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two-cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Min WeiDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Ying ZhangInstitute of Biomedical Engineering, School of Medicine, Shanghai University, Shanghai, China.
Min WangInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Jiayi ZhongInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Wenhui ChaiDepartment of Geriatrics, Xinjiang Changji People's Hospital, Xinjiang, China.
Wenjing HuInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Fengli TaoThe Central Hospital of Karamay, Xinjiang, China.
Luyao WangInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Qi ZhangInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Xianfeng YuDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Rong ShiInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Chenyang LiInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Ziyan SongInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Guanqun ChenDepartment of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Shuyu ZhangDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Jiehui JiangInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China.
Ying HanDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Alzheimer's Disease Neuroimaging Initiative

Funding

National Natural Science Foundation of China 82020108013National Natural Science Foundation of China 82327809Shenzhen Bay Scholars Program, and Tianchi Scholars ProgramSino-German Cooperation Grant M-0759STI2030-Major Projects 2022ZD0211800
6 · The paper itself

Abstract

introductionResearchers have reported an association among amyloid beta (Aβ), tau deposition, and functional networks. Nevertheless, whether plasma biomarkers mediate this process remains unclear.

methodsThree hundred and forty-eight participants with available plasma biomarkers, Aβ positron emission tomography (PET), and resting-state functional magnetic resonance imaging were obtained from two independent cohorts: SILCODE (n = 147) and ADNI (n = 201). Correlations among plasma biomarkers, functional connectivity, and global standardized uptake value ratio (SUVR) were assessed, and mediating effects were analyzed to explore underlying pathways.

resultsPlasma biomarkers (p-tau181, p-tau217, neurofilament light, glial fibrillary acidic protein, Aβ42/40) demonstrated significant correlations with global SUVR and functional connectivity across networks (p < 0.05). Significant functional connectivity variations in different networks were observed across various Aβ stages, with differences mediated by plasma biomarkers. The crucial pathway exhibited fully mediated effects: Aβ PET SUVR-plasma biomarkers (mainly p-tau181 and p-tau217) - various functional networks. DISCUSSION: Our study highlights the core mediating role of plasma biomarkers (mainly p-tau181 and p-tau217) in the progression of Aβ accumulation and in various functional network alterations. HIGHLIGHTS: Plasma biomarkers demonstrated significant mediating effects on Aβ deposition and functional network alterations across different Aβ stages in both East Asian and Western cohorts. Significant functional connectivity variations in different brain networks were observed throughout AD progression in two cohorts, particularly across various Aβ stages. Among all plasma biomarkers, p-tau217 and p-tau181 demonstrated more comprehensive and fully mediating effects compared to other biomarkers, influencing connectivity alterations in the various functional networks. The plasma biomarkers exhibited great potential for tracking pathologic progression, functional network alterations, and early disease identification in East Asian and Western cohorts.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersBraintau ProteinsAgedCohort StudiesFemaleGlial Fibrillary Acidic ProteinHumansMagnetic Resonance ImagingMaleMiddle AgedNeurofilament ProteinsPositron-Emission TomographyAmyloid beta-PeptidesBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsAlzheimer's diseaseamyloid beta positron emission tomographycognitive assessmentfunctional network alterationplasma biomarker

Identifiers

PMID40329658
PMCPMC12056302

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.