ArticleJournal of internal medicine2025
Age-related cardiovascular disease in Down syndrome: A population-based matched cohort study.
Article in Journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cardiovascular risk associated with intellectual disability among adults with type 2 diabetes: a nationwide cohort study in South Korea.EClinicalMedicine · 2026Article
- Immunometabolic interactions in individuals with down syndrome across childhood, adolescence and adulthood in relation to their siblings.Frontiers in immunology · 2026Article
- Unsupervised machine learning integrates genomic variants and EMR to unravel mechanisms of brain hemorrhage and epilepsy as early indicators of Alzheimer's in down syndrome.Alzheimer's research & therapy · 2025Article
- Age-related cardiovascular disease in Down syndrome: A population-based matched cohort study.Journal of internal medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundLife expectancy for individuals with Down syndrome (DS) has increased dramatically. To improve detection and prevention, the risk of age-related cardiovascular disease in this population needs to be better defined.
methodsWe performed a population-based matched cohort study. Through the National Patient Register (NPR) and/or the Medical Birth Register, we identified all individuals born in Sweden between 1946 and 2000 with a diagnosis of DS. Each individual with DS was matched to 50 comparators by sex, birth year, and county of birth. Data on ischemic and hemorrhagic stroke, acute myocardial infarction (AMI), and covariates indicating cardiovascular risk were retrieved from the NPR. Associations between DS and cardiovascular outcomes were estimated using Cox proportional hazards models. We also assessed the influence of cardiovascular risk factors.
resultsWe included 5155 individuals with DS, of which 55% were male. The median age at the end of follow-up was 35 in the DS population and 42 among the comparisons. DS was associated with increased risk of ischemic stroke (hazard ratios [HR] 4.41, 95% confidence intervals [CI] 3.53-5.52) and hemorrhagic stroke (HR 5.14, 95% CI 3.84-6.89). The overall risk of AMI was similar in DS and comparators but increased in young individuals with DS. The risk of ischemic stroke was elevated in individuals with DS with selected atherosclerotic (HR 12.67, 95% CI 7.04-22.78) as well as embolic (HR 10.35, 95% CI 6.69-16.01) risk factors, as compared to comparators without risk factors.
conclusionIndividuals with DS were at increased risk of cardiovascular outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.