ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Brain outcomes with lifestyle change in adults with Down syndrome: Rationale and design for a 12-month randomized trial.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05985486 (The Impact of Weight Loss on Alzheimer's Disease Risk in Adults With Down Syndrome), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Weight Loss on Alzheimer's Disease Risk in Adults With Down Syndrome
Who cites it
3 citing papers in PubMed.
- Understanding Obesity in Individuals with Down Syndrome: Caregiver Perceptions, Awareness, and Motivation.Nutrients · 2026Article
- Alzheimer's Disease Research Center Down Syndrome Cores: Experience from two sites.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Brain outcomes with lifestyle change in adults with Down syndrome: Rationale and design for a 12-month randomized trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Most adults with Down syndrome (DS) will develop pathology associated with Alzheimer's disease (AD). By age 65, the cumulative incidence of dementia exceeds 90%. The available data from trials in typically developed adults suggest the potential for intentional weight loss and changes in dietary intake to prevent or delay the development of AD. However, the potential of weight loss to prevent or delay AD in adults with DS has not been previously examined. In this article, we describe the methods and rationale for a randomized trial that will evaluate the impact of weight loss and dietary intake on factors that may delay the development of AD in adults with DS including cognition, plasma biomarkers, and brain structure. The results of this trial will provide information on if non-pharmacological approaches could delay onset of AD in adults with DS. Clinical Trials Registration: NCT05985486 HIGHLIGHTS: By the age of 65 the cumulative incidence of dementia exceeds 90% in adults with DS. There is a paucity of non-pharmacological interventions to delay AD in adults with DS. Clinical trials in adults without DS suggest that intentional weight loss may improve cognitive function and reduce the risk of developing AD. A randomized trial exploring the impact of weight loss on AD biomarkers in adults with DS is currently underway. This trial will explore if non-pharmacological approaches could delay onset of AD in adults with DS.
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Registered trials
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