Evidence map›Paper›PMID 40329535›Full record

ArticleBiophysical journal2025

5'-tRNA

Kiran Bharat Lokhande, Ashutosh Singh, Rajan Vyas, Shreya Joe, Shailendra Asthana, Kamlesh Pawar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kiran Bharat LokhandeDepartment of Life Sciences, School of Natural Science, Shiv Nadar Institution of Eminence Deemed to Be University, Greater Noida, India; Computational Biophysics and CADD Group, Computational and Mathematical Biology Center, Translational Health Science and Technology Institute, Faridabad, India.
Ashutosh SinghDepartment of Life Sciences, School of Natural Science, Shiv Nadar Institution of Eminence Deemed to Be University, Greater Noida, India.
Rajan VyasDepartment of Life Sciences, School of Natural Science, Shiv Nadar Institution of Eminence Deemed to Be University, Greater Noida, India.
Shreya JoeDepartment of Life Sciences, School of Natural Science, Shiv Nadar Institution of Eminence Deemed to Be University, Greater Noida, India.
Shailendra AsthanaComputational Biophysics and CADD Group, Computational and Mathematical Biology Center, Translational Health Science and Technology Institute, Faridabad, India.
Kamlesh PawarDepartment of Life Sciences, School of Natural Science, Shiv Nadar Institution of Eminence Deemed to Be University, Greater Noida, India; Centre of Excellence in Epigenetics, Department of Life Sciences, School of Natural Science, Shiv Nadar Institution of Eminence Deemed to Be University, Greater Noida, India. Electronic address: kamlesh.pawar@snu.edu.in.

Funding

DBT-Wellcome Trust India Alliance IA/E/20/1/505672Wellcome Trust
6 · The paper itself

Abstract

Toll-like receptor 7 (TLR7), a key member of the TLR family, plays a pivotal role in innate immunity, making it an attractive therapeutic target. However, current synthetic TLR7 agonists are often associated with significant toxicity, highlighting the need for safer, naturally occurring alternatives. Our recent research identified 5'-fragments of tRNA

Indexed as

Toll-Like Receptor 7Base SequenceHumansLigandsMolecular Dynamics SimulationNucleic Acid ConformationThermodynamicsLigandsTLR7 protein, humanToll-Like Receptor 7

Identifiers

PMID40329535
PMCPMC7617684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.