Evidence map›Paper›PMID 40329491›Full record

ArticleEndocrinology, diabetes & metabolism2025

Age-Dependent Effects of Muscle Resting Calcium on Fasting Blood Glucose: Implications for Prediabetes Risk.

Eshwar R Tammineni, Lourdes Figueroa, Michael Fill, Sheila Riazi, Carlo Manno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eshwar R TammineniDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, Illinois, USA.ORCID 0000-0001-7290-9326
Lourdes FigueroaDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, Illinois, USA.
Michael FillDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, Illinois, USA.
Sheila RiaziMalignant Hyperthermia Unit, Department of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Carlo MannoDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, Illinois, USA.

Funding

Mechanisms of couplon-linked skeletal muscle myopathiesR01AR072602 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L, HORRIGAN, FRANK T · 2018 to 2022
$3.3M
The HH: A Large Cohort of Patients with Congenital Myopathies of Uncertain EtiologyR01AR071381 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, RIAZI, SHEILA · 2017 to 2021
$2.7M
NCRR NIH HHS S1055024707NIAMS NIH HHS R01 AR 071381NIAMS NIH HHS R01 AR 072602
6 · The paper itself

Abstract

BACKGROUND AND

aimsSkeletal muscle is the primary site for insulin-mediated glucose uptake and is critical in maintaining whole-body glucose homeostasis. Muscle cells from malignant hyperthermia-susceptible (MHS) individuals exhibit elevated resting cytosolic calcium concentration ([Ca

methodsWe measured resting [Ca

resultsBetween 2013 and 2024, muscle biopsies from 152 subjects (90 MHS, 62 controls) were used to establish primary myotube culture. MHS myotubes exhibited significantly higher resting [Ca

conclusionsElevated resting [Ca

Indexed as

Age FactorsBlood GlucoseCalciumMuscle, SkeletalAdultBiopsyFastingFemaleGlycemic ControlHumansHyperglycemiaMaleMuscle Fibers, SkeletalSex FactorsBlood GlucoseCalciumFBS levelsresting cytosolic calciumskeletal muscletype 2 diabetes

Identifiers

PMID40329491
PMCPMC12055751

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.