Evidence map›Paper›PMID 40329375›Full record

ArticleBMC veterinary research2025

Evaluation of a new method of selective dry cow treatment using microbiological culture and antibiogram results.

Hossein Navaei, Mehdi Vodjgani, Babak Khoramian, Vahid Akbarinejad, Faramarz Gharagozloo, Massoud Talebkhan Garoussi, Amir Momeni

Abstract read
In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hossein NavaeiDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Qareeb Str., Azadi Ave, Tehran, Iran.
Mehdi VodjganiDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Qareeb Str., Azadi Ave, Tehran, Iran. vodjgani@ut.ac.ir.
Babak KhoramianDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Vahid AkbarinejadDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Qareeb Str., Azadi Ave, Tehran, Iran.
Faramarz GharagozlooDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Qareeb Str., Azadi Ave, Tehran, Iran.
Massoud Talebkhan GaroussiDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Qareeb Str., Azadi Ave, Tehran, Iran.
Amir MomeniDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Qareeb Str., Azadi Ave, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to financial issues and the rise in antimicrobial resistance, updating dry cow therapy (DCT) methods is still being researched by scientists worldwide. This investigation aimed to evaluate a new method of selective treatment by choosing an appropriate dry cow antimicrobial product for each cow based on the individual culture and antibiogram results and examining its effects on clinical and subclinical mastitis indices, cure rate, new infection rate, and milk yield during the first 30 days in milk (DIM). MATERIALS AND

methodsA total of 291 Holstein dairy cows were selected from three herds. These cows had a somatic cell count (SCC) > 200,000 (cells/mL) just before drying off, had positive composite milk culture results, and were gradually dried over five days. The milk samples were taken before drying off and on the day after calving (1 DIM) for microbial culture evaluation, as well as 3 days before drying off and between 3 and 7 days postpartum to evaluate SCC. The cows were randomly divided into two groups of control (n = 151) and treatment (n = 140). The control group included cows that were treated with dry cow antimicrobial products regardless of the pathogens involved in mammary infection, and the treatment group contained cows that received dry cow antimicrobial products based on the type of pathogen isolated during culture and the antibiogram results before drying off.

resultsThe results revealed that the cure rate in the treatment group was significantly better than that in the control group (P = 0.0006). In addition, the rate of new intramammary infections (IMI, P = 0.0006) and the rate of clinical mastitis (P = 0.015) decreased in the first 30 DIM in the treatment group. Nevertheless, the SCC and milk yield at the onset of subsequent lactation did not differ significantly between the control and treatment groups (P > 0.05).

conclusionAccording to the findings of our study, based on individual milk culture and antibiogram results, selectively treating cows with appropriate dry cow antimicrobial products had significant benefits for increasing the cure rate of pathogens, lowering the incidence of new IMIs, and minimizing the risk of clinical mastitis in the first 30 DIM.

Indexed as

Anti-Bacterial AgentsMastitis, BovineAnimalsCattleCell CountDairyingFemaleLactationMicrobial Sensitivity TestsMilkAnti-Bacterial AgentsAntibiogramDCTMastitisPathogenSCC

Identifiers

PMID40329375
PMCPMC12057017

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.