ArticleCritical care (London, England)2025
Depression or anxiety and long-term mortality among adult survivors of intensive care unit: a population-based cohort study.
Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of Virtual Reality-Based Early Rehabilitation Strategies on Pain, Sleep, Anxiety, Balance, Cognition, and Limb Motor Function in Adult Intensive Care Unit Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Comparative effectiveness of non-pharmacological interventions on health-related quality of life in ICU patients: a network meta-analysis.Frontiers in medicine · 2026Pooled it
- Acute Respiratory Failure Survivors' Perspectives on Patient-Centered Communication: A Mixed Methods Study.Critical care explorations · 2026Observational
- The quality and reliability of short videos about pulmonary hypertension on Bilibili and TikTok: a cross-sectional study.BMC cardiovascular disorders · 2026Article
- The Hidden Burden After Critical Illnesses: A Systematic Review of Psychological Outcomes and Their Associated Factors Among ICU Survivors (2021-2025).Journal of multidisciplinary healthcare · 2026Review
- Association between isolation room admission in intensive care units and long-term psychiatric disorders: a nationwide cohort study.Critical care (London, England) · 2025Article
- Association among objective and subjective sleep duration, depressive symptoms and all-cause mortality: the pathways study.BMC psychiatry · 2025Article
- Consensus-Based Recommendations for Assessing Post-Intensive Care Syndrome: A Systematic Review.Journal of clinical medicine · 2025Review
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Abstract
backgroundMany patients who survive intensive care unit (ICU) stays experience persistent mental impairments. It is estimated that one-third of ICU survivors suffer from psychiatric disorders. However, research into how these disorders affect long-term outcomes in this population is scarce. Therefore, the aim of this study is to investigate the association between depression or anxiety and long-term mortality among ICU survivors.
methodsThis population-based cohort study included patients admitted to the ICU between January 1, 2015 and December 31, 2019, who survived at least 1 year after ICU discharge. Exclusions were made for patients admitted for non-medical reasons and those who had been in the ICU in the previous 2 years, and 799,645 patients were included in the study. Follow-up data were obtained for up to 7 years. The primary outcome was long-term cumulative mortality. Mortality rates for patients with and without diagnoses of depression or anxiety were compared.
resultsOf the 799,645 adult ICU survivors, 98,530 (12.3%) were newly diagnosed with depression or anxiety post-discharge, and 265,092 (33.2%) had been diagnosed prior to ICU admission. Multivariate Cox proportional hazards regression analysis revealed that the adjusted hazard ratio (HR) for long-term mortality was 1.17 (95% CI, 1.16-1.19) for those newly diagnosed with depression or anxiety, 1.28 (95% CI, 1.26-1.30) for depression alone, and 1.08 (95% CI, 1.06-1.11) for anxiety alone. For those with prior diagnoses, the adjusted HR was 1.08 (95% CI, 1.07-1.09) overall, 1.12 (95% CI, 1.11-1.14) for depression, and 1.04 (95% CI, 1.03-1.05) for anxiety.
conclusionsICU survivors newly diagnosed with depression or anxiety exhibit higher long-term mortality rates compared to those without such diagnoses, including those diagnosed before ICU admission. Particularly, newly diagnosed depression is associated with an elevated mortality rate. These findings underscore the need for psychological interventions to enhance long-term survival among ICU survivors.
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