ArticleBiological research2025
Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity.
Article in Biological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Profiling metabolites of Ficus natalensis hochst. fruit by UPLC-MS/MS and evaluation of anti-inflammatory activity.Scientific reports · 2026Article
- Protective Effects ofToxics · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this work was to examine the fundamental mechanisms of reproductive toxicity in rat models following exposure to Fenpropathrin (FNP). Furthermore, our study explores the novel impacts of Date palm kernel extract (DPK) on these detrimental outcomes.
methodsThirty male Wistar rats were used in the investigation. They were split into six groups: one group received corn oil as a control; two groups received DPK at 200 mg/kg and 400 mg/kg; a group received FNP at 4.7 mg/kg; and two combination groups received DPK and FNP at 200 mg/kg and 400 mg/kg, respectively for 60 days.
resultsFNP caused oxidative stress, reduced sperm count, and impaired motility. FNP decreased the expression of the StAR gene and reduced serum testosterone levels. We assessed the histological alterations. In a dose-dependent way, the concurrent administration of DPK extract successfully decreased all the toxicological parameters.
conclusionsWhen taken orally, DPK extract may protect against FNP-induced male reproductive toxicity.
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