ArticleBMC pediatrics2025
Exploring the types of airway inflammation in hospitalized children with asthma.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05800379 (Study on Hospitalization of Children With Bronchial Asthma), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on Hospitalization of Children With Bronchial Asthma
Who cites it
1 citing paper in PubMed.
- Beyond the Usual Suspects: Unmasking Low-T2 Asthma in Children.Journal of clinical medicine · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a heterogeneous disease. Precise and personalized treatment is urgently needed to reduce the disease's burden. Thus, exploring the different types of airway inflammation in hospitalized children with asthma is beneficial for accurately managing childhood asthma.
methodsThis retrospective study was conducted on children and adolescents with asthma who were hospitalized for asthma exacerbations. The classification cut-off values of blood eosinophil (EOS) were 150 (Standard 1), 300 (Standard 2), and 470/µL (Standard 3), respectively. Combined with specific IgE (sIgE, 0.7 kU/L), these individuals were divided into four airway inflammation types. We compared the proportion and characteristics of different airway inflammation. The P value < 0.05 indicated statistical significance.
resultsA total of 351 children were enrolled in our study. Based on standard 1, 39.3% of the subjects were classified as Only-atopy group, 11.7% displayed Only-EOS group, 29.6% exhibited Type 2 (T2)-high group, and 19.4% exhibited T2-low group. Under standard 2, 51.3% of the subjects were classified as the Only-atopy group, 5.4% displayed the Only-EOS group, 17.7% exhibited the T2-high group, and 25.6% exhibited the T2-low group. In standard 3, 57.8% of the subjects were classified as the Only-atopy group, 2.9% displayed the Only-EOS group, 11.1% exhibited the T2-high group, and 28.2% exhibited the T2-low group. Furthermore, our findings indicate that patients with T2 low airway inflammation have a longer time from onset to admission, a longer hospitalization time, a lower proportion of atopic dermatitis, and a higher proportion of siblings.
conclusionRegardless of the classification standard employed, the distribution of Only-atopy and Only-EOS was similar in different age periods. Moreover, the types of airway inflammation exhibited a consistent temporal pattern. The classification of airway inflammation in children based on peripheral blood and sIgE levels is a valuable tool for accurately treating asthma.
trial registrationThe study was registered at https://clinicaltrials.gov/ with the number: NCT05800379 on 05/04/2023.
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