Evidence map›Paper›PMID 40329153›Full record

ArticleJournal of imaging informatics in medicine2026

Decoding the Rotation Effect: A Retrospective Analysis of Lesion Orientation and Its Impact on Wavelet-Based Radiomics Feature Extraction and Lung Cancer Classification.

Lun Matthew Wong, Qi-Yong Hemis Ai, Ho Sang Leung, Tifffany Yuen-Tung So, Kuo Feng Hung, Yuet-Ting Chan, Ann Dorothy King

Abstract read
In one paragraph

Article in Journal of imaging informatics in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lun Matthew WongDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, LG/F, Cancer Centre, Shatin, New Territory, HKSAR, China. lun.m.wong@cuhk.edu.hk.
Qi-Yong Hemis AiDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, LG/F, Cancer Centre, Shatin, New Territory, HKSAR, China.
Ho Sang LeungDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Hospital Authority - New Territory East Cluster, HKSAR, China.
Tifffany Yuen-Tung SoDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, LG/F, Cancer Centre, Shatin, New Territory, HKSAR, China.
Kuo Feng HungDepartment of Applied Oral Sciences & Community Dental Care, Faculty of Dentistry, The University of Hong Kong, HKSAR, China.
Yuet-Ting ChanDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, LG/F, Cancer Centre, Shatin, New Territory, HKSAR, China.
Ann Dorothy KingDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, LG/F, Cancer Centre, Shatin, New Territory, HKSAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wavelet decomposition (WD), widely used in radiomics, redistributes information among derived wavelet components when the input is rotated. This redistribution may alter predictions for the same lesion when scanned at different angles. Despite its potential significance, this vulnerability has frequently been overlooked in radiomic studies while its impact remains poorly understood. Therefore, this study aims to investigate how variations in lesion orientation affect both WD and non-WD radiomic feature values, and subsequently, model performance. We analyzed CT radiomics of primary non-small-cell lung cancer (NSCLC). Prior to feature extraction, we introduced random rotations ranging from 5° to 80° to the tumors. Their effects were quantified by evaluating the percentage difference (

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsRadiographic Image Interpretation, Computer-AssistedTomography, X-Ray ComputedWavelet AnalysisAgedFemaleHumansMaleMiddle AgedRadiomicsRetrospective StudiesRotationComputer tomographyNon-small-cell lung cancerRadiomicsReproducibilityWavelet analysis

Identifiers

PMID40329153
PMCPMC12920822

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.