Evidence map›Paper›PMID 40329138›Full record

ArticleNeuroscience bulletin2025

A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response.

Ling Zheng, Qiaosen Shen, Tong Zhao, Qingsong Liu, Zihao Huang, Feng Zhao, Mengqian Zhang, Yongdong Song, Daogong Zhang, Dong Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ling ZhengHarbin Institute of Technology, Harbin, 150001, Heilongjiang, China.
Qiaosen ShenSchool of Life Science, Southern University of Science and Technology, Shenzhen, 518055, China.
Tong ZhaoDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Qingsong LiuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Zihao HuangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Feng ZhaoExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250000, China.
Mengqian ZhangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Yongdong SongDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, 250000, China.
Daogong ZhangDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, 250000, China. Zhangdaogong1978@163.com.ORCID http://orcid.org/0000-0002-2446-1595
Dong LiuSchool of Life Science, Southern University of Science and Technology, Shenzhen, 518055, China. liud@sustech.edu.cn.ORCID http://orcid.org/0000-0001-6993-8978
Fangyi ChenDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China. chenfy@sustech.edu.cn.ORCID http://orcid.org/0000-0002-5024-6215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zebrafish larvae are useful for identifying chemicals against lateral line (LL) hair cell (HC) damage and this type of chemical screen mainly focuses on searching for protectors against cell death. To expand the candidate pool of HC protectors, a self-built acoustic escape response (AER)-detecting system was developed to apply both low-frequency near-field sound transmission and AER image acquisition/processing modules. The device quickly confirmed the changed LL HC functions caused by most known ototoxins, protectors, and neural transmission modifiers, or knockdown of LL HC-expressing genes. With ten devices wired in tandem, five 'hit' chemicals were identified from 124 cyclin-dependent kinase inhibitors to partially restore cisplatin-damaged AER in less than a day. AS2863619, ribociclib, and SU9516 among the hits, protected the HCs in the mouse cochlea. Therefore, using free-swimming larval zebrafish, the self-made AER-detecting device can efficiently identify compounds that are protective against HC damage, including cell death and loss-of-function.

Indexed as

Escape ReactionHair Cells, AuditoryLateral Line SystemAnimalsCisplatinDrug Evaluation, PreclinicalLarvaMiceZebrafishCisplatinAcoustic escape responseFunctional screeningHair cellLateral lineLow-frequency soundZebrafish

Identifiers

PMID40329138
PMCPMC12433417

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.