Evidence map›Paper›PMID 40329131›Full record

ArticleClinical rheumatology2025

Osteoarthritis and the risk of sleep apnea: a general population-based cohort study.

Yanqiu Zhu, Qiao Jiang, Yuqing Zhang, Dongxing Xie, Zidan Yang, Na Lu, Chao Zeng, Guanghua Lei, Jie Wei, Tuo Yang

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Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yanqiu Zhu *Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Qiao Jiang *Departmenf of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yuqing ZhangMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Dongxing XieDepartmenf of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zidan YangHunan Key Laboratory of Joint Degeneration and Injury, Changsha, Hunan, China.
Na LuArthritis Research Canada, Richmond, BC, Canada.
Chao ZengXiangya School of Public Health, Central South University, Changsha, Hunan, China.
Guanghua LeiDepartmenf of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Jie WeiXiangya School of Public Health, Central South University, Changsha, Hunan, China.
Tuo YangDepartmenf of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. yangtuo@csu.edu.cn.ORCID http://orcid.org/0000-0001-6363-3356

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOsteoarthritis (OA) is the most common joint disease, leading to pain and inflammation, two risk factors for sleep apnea (SA). We aimed to examine whether OA may increase the risk of incident SA, a common source of mortality and sudden death.

methodUsing data from the IQVIA Medical Research Database, we conducted three cohort studies (i.e., knee, hip, and hand cohort) among individuals aged 50 years or older. For each patient with incident OA, up to five non-OA individuals were matched by age, sex, entry-time, and BMI. We calculated the incidence rate of SA for the OA and non-OA cohorts, respectively, and examined the relation of OA to the risk of incident SA using a Cox proportional hazard model adjusting for potential confounders.

resultsDuring the follow-up, 869 SA cases occurred in 58,674 patients with knee OA and 2,186 in 235,850 non-OA individuals (2.29 vs. 1.41/1000 person-years). Compared with the non-OA cohort, the multivariable-adjusted hazard ratio (HR) of SA in the knee OA cohort was 1.45 (95% confidence interval [CI]: 1.34-1.56). A higher risk of SA was also observed among patients with incident hip OA (adjusted HR: 1.45, 95%CI: 1.28-1.66) and hand OA (adjusted HR: 1.50, 95%CI: 1.26-1.78) than the matched non-OA individuals.

conclusionsThis general population-based study provides the first evidence that patients with knee, hip, and hand OA may have an increased risk of incident SA. Strategies aimed at screening, prevention, and treatment of SA could be developed to reduce the disease burden in OA patients.

Indexed as

OsteoarthritisOsteoarthritis, HipOsteoarthritis, KneeSleep Apnea SyndromesAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRisk FactorsCohort studiesOsteoarthritisSleep disorders

Identifiers

PMID40329131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.