Evidence map›Paper›PMID 40329130›Full record

ArticleClinical rheumatology2025

Associations between comorbidities and patient-reported outcomes in axial spondyloarthritis: data from a single-center real-world cohort.

Grzegorz Biedroń, Mateusz Wilk, Jarosław Nowakowski, Piotr Kuszmiersz, Zofia Guła, Magdalena Strach, Alen Brkic, Glenn Haugeberg, Mariusz Korkosz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Grzegorz BiedrońDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 31-315, Cracow, Poland. grzegorz.biedron@uj.edu.pl.ORCID http://orcid.org/0000-0002-2643-9818
Mateusz WilkDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 31-315, Cracow, Poland.ORCID http://orcid.org/0000-0001-7967-0880
Jarosław NowakowskiDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 31-315, Cracow, Poland.ORCID http://orcid.org/0000-0002-8748-7581
Piotr KuszmierszDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 31-315, Cracow, Poland.ORCID http://orcid.org/0000-0002-2031-6657
Zofia GułaDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 31-315, Cracow, Poland.ORCID http://orcid.org/0000-0002-8698-6469
Magdalena StrachDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 31-315, Cracow, Poland.ORCID http://orcid.org/0000-0001-5449-0680
Alen BrkicDivision of Rheumatology, Department of Internal Medicine, Sørlandet Hospital, Kristiansand, Norway.ORCID http://orcid.org/0000-0002-6371-8947
Glenn HaugebergDivision of Rheumatology, Department of Internal Medicine, Sørlandet Hospital, Kristiansand, Norway.ORCID http://orcid.org/0000-0002-9279-5191
Mariusz KorkoszDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 31-315, Cracow, Poland.ORCID http://orcid.org/0000-0002-1749-9739

Funding

Narodowe Centrum Badań i Rozwoju 0026/2019-00
6 · The paper itself

Abstract

introductionComorbidities are frequently present in patients with axial spondyloarthritis (axSpA) and may contribute to poorer health-related outcomes. Patient-reported outcomes (PROs) serve as tools to assess the patient's perspective on the burden of the disease. The study aimed to evaluating the impact of comorbidities on selected PROs in axSpA.

methodAdult patients diagnosed with axSpA based on ASAS classification criteria were included in this cross-sectional study. Data collected included comorbidities and PROs [Health Assessment Questionnaire (HAQ), Multi-Dimensional Health Assessment Questionnaire (MDHAQ), 36-Item Short Form Health Survey (SF-36), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Bath Ankylosing Spondylitis Functional Index (BASFI)].

resultsIn total, 323 participants were included in the study (44.0% female). Multimorbidity and extended multimorbidity were observed in 63.8% and 38.7% of patients, respectively. Extended multimorbidity was associated with higher HAQ (0.5 [0.1-1.0] vs. 0.3 [0.0-0.8], p < 0.01) and MDHAQ scores (0.3 [0.0-0.6] vs. 0.1 [0.0-0.5], p = 0.03). The BASDAI score was higher in patients with three or more comorbidities than in patients with no comorbidities (2.8 [1.7-4.3] vs. 1.9 [0.9-3.6], p < 0.01). The number of comorbidities was associated with higher scores in the mental health (β = 0.20, p < 0.01) and vitality (β = 0.16, p = 0.02) domains of the SF-36 questionnaire.

conclusionsMultimorbidity was present in almost two-thirds of cases. Extended multimorbidity was associated with poorer physical functioning, HAQ, MDHAQ, and BASDAI scores, whereas multimorbidity was related to better scores in the mental health and vitality domains. The impact of comorbidities on PROs in axSpA should not be overlooked. Key Points • Multimorbidity is frequent among axial spondyloarthritis' patients. • Only extended multimorbidity (presence of two or more additional diseases, excluding axial spondyloarthritis) was found to be associated with poorer results of patient-reported outcomes, in particular these regarding physical functioning. • Multimorbidity might influence positively some domains of quality of life such as mental health or vitality. • The findings included in the study support the belief that in patients with spondyloarthritis comorbidities might impact patient-reported outcomes which are important when assessing disease activity and response to treatment and should not be disregarded.

Indexed as

Axial SpondyloarthritisPatient Reported Outcome MeasuresSpondylarthritisAdultComorbidityCross-Sectional StudiesFemaleHumansMaleMiddle AgedMultimorbidityQuality of LifeSeverity of Illness IndexSurveys and QuestionnairesAxial spondyloarthritisComorbidityMultimorbidityPatient-reported outcomeQuality of life

Identifiers

PMID40329130
PMCPMC12141145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.