ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025
Clinical value of fat depositions in different lumbar areas on spine degeneration and clinical outcomes.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Adipose-Derived Stem Cells From Human Lumbar Subcutaneous Tissue in Obesity: Inflammatory Microenvironment Promotes Differentiation Capacity.Stem cells international · 2026Article
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9 authors.
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Abstract
purposeThis study aimed to compare the distribution characteristics and clinical values of the intramuscular, epimuscular and subcutaneous fat depositions in lumbar areas in lumbar spinal stenosis (LSS) patients and healthy controls.
methodsThe study retrospectively reviewed 236 LSS patients undergoing posterior lumbar interbody fusion with follow-up visits. We also recruited 115 healthy controls from the community. All participants had undergone magnetic resonance imaging for the measurements of fat infiltration (FI) of the intramuscular fat and epimuscular fat of paraspinal extensor muscles (PEM, including multifidus [MF] and erector spinae [ES]), and subcutaneous fat tissue thickness. The evaluation of lumbar degeneration changes included intervertebral disk degeneration (IVDD) and Modic changes in healthy controls. Postoperative mechanical complications were measured at 1-year follow-up in LSS patients.
resultsThe LSS patients presented with significantly higher intramuscular FI and epimuscular FI when compared with the healthy controls (p < 0.001). The severe IVDD group exhibited significantly higher epimuscular FI than the mild-to-moderate IVDD group (p < 0.01), and the Modic group exhibited significantly higher intramuscular FI (p < 0.05). In terms of clinical outcomes, the patients with mechanical complications presented with higher intramuscular FI (p < 0.05). In binary logistic regressions, the epimuscular FI was an independent factor of IVDD (OR = 1.209 [1.048-1.395], p = 0.009) for LSS patients, and the intramuscular FI was an independent factor of mechanical complications (OR = 1.053 [1.017-1.090], p < 0.001).
conclusionThe fat depositions in different lumbar areas might have specific distribution characteristics and different correlations to lumbar degenerative changes and clinical outcomes. Orthopedists should measure fat depositions in different lumbar areas separately during preoperative evaluation.
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