Evidence map›Paper›PMID 40329121›Full record

ArticleJournal of natural medicines2025

Identification of specialized metabolites from Artocarpus lacucha as potent α-glucosidase and acetylcholinesterase inhibitors: enzyme kinetic, in vitro and in silico study.

Weerasak Songoen, Witthawat Phanchai, Johann Schinnerl, Lothar Brecker, Morakot Thabpho, Sorachat Tharamak, Wanchai Pluempanupat, Siriphan Sukkhaeng, Sasiwimol Chansuthep

Abstract read
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Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weerasak SongoenCentral Laboratory and Greenhouse Complex, Research and Academic Service Center, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, 73140, Thailand. fagrwss@ku.ac.th.ORCID http://orcid.org/0000-0002-4517-1677
Witthawat PhanchaiDepartment of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
Johann SchinnerlDepartment of Botany and Biodiversity Research, Faculty of Life Sciences, University of Vienna, Rennweg 14, 1030, Vienna, Austria. johann.schinnerl@univie.ac.at.
Lothar BreckerDepartment of Organic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Morakot ThabphoFaculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen, Nakhon Pathom, 73140, Thailand.
Sorachat TharamakDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Special Research Unit for Advanced Magnetic Resonance, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
Wanchai PluempanupatDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Special Research Unit for Advanced Magnetic Resonance, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
Siriphan SukkhaengCentral Laboratory and Greenhouse Complex, Research and Academic Service Center, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, 73140, Thailand.
Sasiwimol ChansuthepCentral Laboratory and Greenhouse Complex, Research and Academic Service Center, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, 73140, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artocarpus species play an important role in the folk medicine of various ethnic groups in Africa, South Asia, and Southeast Asia. In the present study, we investigated the potential of Artocarpus lacucha in the treatment of diabetes mellitus and Alzheimer's disease. During this work, one previously undescribed compound (1), along with 10 known compounds (2-11), were isolated from the leaves of Artocarpus lacucha. Their molecular structures were established using NMR and HRMS experiments. Among the tested compounds, flavan-benzofuran artocarpinol B, displayed significant α-glucosidase inhibitory activity with an IC

Indexed as

alpha-GlucosidasesArtocarpusCholinesterase InhibitorsGlycoside Hydrolase InhibitorsPlant ExtractsAcetylcholinesteraseHumansKineticsMolecular Docking SimulationMolecular StructurePlant LeavesAcetylcholinesterasealpha-GlucosidasesCholinesterase InhibitorsGlycoside Hydrolase InhibitorsPlant ExtractsAcetylcholinesterase inhibitionArtocarpus lacuchaDiabetes mellitusMolecular dockingα-Glucosidase inhibition

Identifiers

PMID40329121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.